Reactions of acryl thioamides with iminoiodinanes as a one-step synthesis of N-sulfonyl-2,3-dihydro-1,2-thiazoles.

IF 2.2 4区化学 Q2 CHEMISTRY, ORGANIC

Beilstein Journal of Organic Chemistry Pub Date : 2025-07-10 eCollection Date: 2025-01-01 DOI:10.3762/bjoc.21.104

Vladimir G Ilkin, Pavel S Silaichev, Valeriy O Filimonov, Tetyana V Beryozkina, Margarita D Likhacheva, Pavel A Slepukhin, Wim Dehaen, Vasiliy A Bakulev

引用次数: 0

Abstract

A one-step method has been developed for the preparation of 2,3-dihydro-2-sulfonyl-3,4,5-substituted 1,2-thiazoles by the reaction of acryl thioamides and iminoiodinanes. A library of 31 examples of tetrasubstituted 1,2-thiazoles was thus synthesized in high yields. The effectiveness of the synthesis method for these poorly studied 1,2-thiazoles was confirmed by scaling the reaction using gram amounts of the starting thioamide.

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丙烯基硫胺与亚胺碘胺反应一步合成n -磺酰-2,3-二氢-1,2-噻唑。

研究了丙烯硫胺与亚胺碘胺一步法合成2,3-二氢-2-磺酰基-3,4,5-取代1,2-噻唑的方法。以高收率合成了31个四取代1,2-噻唑类化合物。用克数的起始硫胺对反应进行缩放，证实了该合成方法对这些研究较少的1,2-噻唑的有效性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Beilstein Journal of Organic Chemistry 化学-有机化学

CiteScore

4.90

自引率

3.70%

发文量

167

审稿时长

1.4 months

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