Hydrogen-Bond Cross-Linking between Chitosan and Urethane-Modified Polycaprolactone: Influence of PCL Structure on Cryogel Properties.

IF 5.4 2区医学 Q2 MATERIALS SCIENCE, BIOMATERIALS

ACS Biomaterials Science & Engineering Pub Date : 2025-07-15 DOI:10.1021/acsbiomaterials.5c00684

Surisara Phangkam, Pichamon Kiatwuthinon, Chantiga Choochottiros

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Abstract

Cryogels are macroporous biomaterials that exhibit shape recovery, making them attractive for various applications. Here, we report a simple method for fabricating a chitosan-based cryogel by modifying polycaprolactone with a urethane linkage (PCLU) and mixing it with a chitosan solution. The network structure was formed via hydrogen bond cross-linking. The effect of PCLU structures, such as star-shaped (stPCLU) and linear (LPCLU), on the physical properties of chitosan-based cryogels (CstU and CLU) was investigated. The CstU provided a large pore size and a high swelling degree due to the arm structure of stPCLU, which restricted chain mobility and alignment. In the case of CLU, the linear structure of LPCLU facilitated chain alignment and high crystallinity, resulting in high compressive strength and small pore size. Moreover, the synergistic effect of PCLU content and hydrogen bond cross-linking provided high compressive strength and rheological properties. In addition, biocompatibility testing showed that CstU and CLU are nontoxic to cells and promote cell adherence on their surfaces. Therefore, CstU and CLU have the potential for development in biomedical applications.

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壳聚糖与聚氨酯改性聚己内酯间的氢键交联：PCL结构对低温凝胶性能的影响。

低温材料是一种具有形状恢复功能的大孔生物材料，具有广泛的应用前景。本文报道了一种简单的制备壳聚糖基低温凝胶的方法，即用氨基甲酸乙酯（PCLU）修饰聚己内酯，并将其与壳聚糖溶液混合。通过氢键交联形成网络结构。研究了星形结构（stPCLU）和线型结构（LPCLU）对壳聚糖基冷冻材料（CstU和CLU）物理性能的影响。由于stPCLU的臂状结构，CstU的孔径大，膨胀度高，限制了链的迁移和排列。在CLU的情况下，LPCLU的线性结构有利于链排列和高结晶度，从而具有高抗压强度和小孔径。此外，PCLU含量与氢键交联的协同效应提供了较高的抗压强度和流变性能。此外，生物相容性测试表明，CstU和CLU对细胞无毒，并促进细胞在其表面的粘附。因此，CstU和CLU在生物医学应用方面具有发展潜力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

ACS Biomaterials Science & Engineering Materials Science-Biomaterials

CiteScore

10.30

自引率

3.40%

发文量

413

期刊介绍： ACS Biomaterials Science & Engineering is the leading journal in the field of biomaterials, serving as an international forum for publishing cutting-edge research and innovative ideas on a broad range of topics: Applications and Health – implantable tissues and devices, prosthesis, health risks, toxicology Bio-interactions and Bio-compatibility – material-biology interactions, chemical/morphological/structural communication, mechanobiology, signaling and biological responses, immuno-engineering, calcification, coatings, corrosion and degradation of biomaterials and devices, biophysical regulation of cell functions Characterization, Synthesis, and Modification – new biomaterials, bioinspired and biomimetic approaches to biomaterials, exploiting structural hierarchy and architectural control, combinatorial strategies for biomaterials discovery, genetic biomaterials design, synthetic biology, new composite systems, bionics, polymer synthesis Controlled Release and Delivery Systems – biomaterial-based drug and gene delivery, bio-responsive delivery of regulatory molecules, pharmaceutical engineering Healthcare Advances – clinical translation, regulatory issues, patient safety, emerging trends Imaging and Diagnostics – imaging agents and probes, theranostics, biosensors, monitoring Manufacturing and Technology – 3D printing, inks, organ-on-a-chip, bioreactor/perfusion systems, microdevices, BioMEMS, optics and electronics interfaces with biomaterials, systems integration Modeling and Informatics Tools – scaling methods to guide biomaterial design, predictive algorithms for structure-function, biomechanics, integrating bioinformatics with biomaterials discovery, metabolomics in the context of biomaterials Tissue Engineering and Regenerative Medicine – basic and applied studies, cell therapies, scaffolds, vascularization, bioartificial organs, transplantation and functionality, cellular agriculture