Green genes from blue greens: challenges and solutions to unlocking the potential of cyanobacteria in drug discovery.

IF 10.2 1区化学 Q1 BIOCHEMISTRY & MOLECULAR BIOLOGY

Natural Product Reports Pub Date : 2025-07-15 DOI:10.1039/d5np00016e

Benjamin Philmus, Nicole E Avalon, Yousong Ding, Drew T Doering, Alessandra S Eustáquio, William H Gerwick, Hendrik Luesch, Jimmy Orjala, Shaz Sutherland, Arnaud Taton, Daniel Udwary

引用次数: 0

Abstract

Cyanobacteria are prolific producers of biologically active compounds that are important in influencing ecology, behavior of interacting organisms, and as leads in drug discovery efforts. Here we discuss the challenges faced by all natural product researchers, especially those that focus on cyanobacteria, and then describe progress that has been made in these areas. We also propose some solutions, paths forward, and thoughts for consideration on these challenges.

查看原文本刊更多论文

来自蓝色绿色的绿色基因：挑战和解决方案，以解锁药物发现蓝藻的潜力。

蓝藻是多产的生物活性化合物的生产者，在影响生态，相互作用的生物体的行为是重要的，并在药物发现努力的领导。在这里，我们讨论所面临的挑战，所有天然产品的研究人员，特别是那些专注于蓝藻，然后描述已在这些领域取得的进展。针对这些挑战，我们也提出了一些解决方案、前进路径和思考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Natural Product Reports 化学-生化与分子生物学

CiteScore

21.20

自引率

3.40%

发文量

127

审稿时长

1.7 months

期刊介绍： Natural Product Reports (NPR) serves as a pivotal critical review journal propelling advancements in all facets of natural products research, encompassing isolation, structural and stereochemical determination, biosynthesis, biological activity, and synthesis. With a broad scope, NPR extends its influence into the wider bioinorganic, bioorganic, and chemical biology communities. Covering areas such as enzymology, nucleic acids, genetics, chemical ecology, carbohydrates, primary and secondary metabolism, and analytical techniques, the journal provides insightful articles focusing on key developments shaping the field, rather than offering exhaustive overviews of all results. NPR encourages authors to infuse their perspectives on developments, trends, and future directions, fostering a dynamic exchange of ideas within the natural products research community.