Association Between Prenatal Exposure to Traffic-Related Air Pollution and Orofacial Clefts Among Newborns in New York State, Excluding New York City (2000–2019)

IF 1.6 4区医学 Q4 DEVELOPMENTAL BIOLOGY

Birth Defects Research Pub Date : 2025-07-16 DOI:10.1002/bdr2.2503

Douglas Done, Michele Herdt, Tabassum Z. Insaf, Beth Feingold, Akiko Hosler

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引用次数: 0

Abstract

Background

Prenatal exposure to tobacco smoke is strongly associated with the development of orofacial clefts. Traffic-related air pollution (TRAP) has many of the same toxic combustion byproducts as burning tobacco, such as benzene and PM_2.5, and may therefore act through similar pathways to cause harm to developing fetuses. Since concentrations of TRAP are highest close to the roadway, they can be assessed using distance-weighted traffic density (DWTD).

Methods

A case–control study of birthing parent–newborn pairs was conducted among children born between January 1, 2000, and December 31, 2019, to people residing in New York State (NYS), excluding New York City. Cases of cleft lip alone, cleft palate alone, and cleft lip with cleft palate were identified from the NYS Birth Defects Registry. Orofacial clefts were also analyzed as an aggregated group. Controls without diagnosed major birth defects were randomly selected from hospital discharge records. DWTD measured in vehicles per day (VPD) was calculated from NYS Department of Transportation traffic data. A multivariate logistic regression model, adjusted for the birthing parent's age, race, ethnicity, and census tract-level disadvantage, was constructed to evaluate the association between orofacial clefts and DWTD.

Results

There was a statistically significant adjusted odds ratio (aOR) comparing the DWTD ≥ 500 VPD group to the DWTD reference group (< 500 VPD) found only among orofacial clefts as an aggregate group (aOR = 1.13 [1.04–1.22]).

Conclusions

The current study, covering 20 years of case collection, generally supports the DWTD's potential risk for orofacial clefts. Larger observational studies are warranted to further investigate associations between DWTD and individual categories of orofacial clefts.

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2000-2019年纽约州（不包括纽约市）新生儿产前暴露于交通相关空气污染与口面部裂的关系

背景产前暴露于烟草烟雾与口面部裂的发展密切相关。与交通有关的空气污染（TRAP）具有许多与燃烧烟草相同的有毒燃烧副产品，如苯和PM2.5，因此可能通过类似的途径对发育中的胎儿造成伤害。由于TRAP浓度在靠近道路的地方最高，因此可以使用距离加权交通密度（DWTD）来评估它们。方法对2000年1月1日至2019年12月31日期间在纽约州（不包括纽约市）出生的儿童进行分娩父母-新生儿对的病例对照研究。唇裂、腭裂和唇裂合并腭裂的病例均从纽约出生缺陷登记处进行鉴定。口面裂隙也作为一个综合组进行分析。没有诊断出重大出生缺陷的对照组从出院记录中随机选择。以每天车辆计算的DWTD （VPD）是根据纽约运输部的交通数据计算的。构建了一个多变量logistic回归模型，调整了出生父母的年龄、种族、民族和人口普查水平上的劣势，以评估口面部裂与DWTD之间的关系。结果DWTD≥500 VPD组与DWTD参照组（< 500 VPD）的校正优势比（aOR）仅在唇腭裂合并组中有统计学意义（aOR = 1.13[1.04-1.22]）。结论：目前的研究涵盖了20年的病例收集，总体上支持DWTD对唇腭裂的潜在风险。更大规模的观察性研究是必要的，以进一步调查DWTD与个别类别的口面部唇裂之间的关系。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Birth Defects Research Medicine-Embryology

CiteScore

3.60

自引率

9.50%

发文量

153

期刊介绍： The journal Birth Defects Research publishes original research and reviews in areas related to the etiology of adverse developmental and reproductive outcome. In particular the journal is devoted to the publication of original scientific research that contributes to the understanding of the biology of embryonic development and the prenatal causative factors and mechanisms leading to adverse pregnancy outcomes, namely structural and functional birth defects, pregnancy loss, postnatal functional defects in the human population, and to the identification of prenatal factors and biological mechanisms that reduce these risks. Adverse reproductive and developmental outcomes may have genetic, environmental, nutritional or epigenetic causes. Accordingly, the journal Birth Defects Research takes an integrated, multidisciplinary approach in its organization and publication strategy. The journal Birth Defects Research contains separate sections for clinical and molecular teratology, developmental and reproductive toxicology, and reviews in developmental biology to acknowledge and accommodate the integrative nature of research in this field. Each section has a dedicated editor who is a leader in his/her field and who has full editorial authority in his/her area.