Perspectives on the fighting against Acinetobacter baumannii via plants as promising weapons against multidrug-resistant bacteria: a systematic review

IF 1.9 4区医学 Q2 INTEGRATIVE & COMPLEMENTARY MEDICINE

Journal of Herbal Medicine Pub Date : 2025-04-29 DOI:10.1016/j.hermed.2025.101025

Majid Sezavar , Vahid Soheili , Zarrin Mahnia , Ahmad Bagheri Moghaddam , Benyamin Fazli

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引用次数: 0

Abstract

Objectives and aims

Multi-drug resistant (MDR) Acinetobacter baumannii is a prominent cause of various nosocomial infections including ventilator-associated pneumonia, bacteremia, meningitis, urinary tract infections, and wound infections. Therefore, finding new compounds or therapeutic approaches to overcome this pathogen is necessary. This review systematically investigated the effects of herbal components with antibacterial and anti-biofilm activities against standard and clinical isolates of A. baumannii.

Methods

A search was conducted on four prominent academic databases, namely Web of Sciences, PubMed, Medline, and Scopus databases, for articles published by March 18, 2023. The research followed the seven procedures outlined in the Cochrane Handbook. Multiple keywords were used to search for papers, including ‘A. baumannii’ in combination with ‘herbal medicine’ or ‘plant compound’, as well as ‘biofilm’ or ‘antibacterial’ or ‘antimicrobial’.

Results

Overall, 29 articles that considered the effects of 133 plant species on A. baumannii were reviewed. The studies used micro/macro-broth dilution method and/or agar well/disk diffusion assay to assess the antimicrobial properties of herbal derived compounds. Several compounds had significant antibacterial and bactericidal effects against multi-drug resistant bacterium, A. baumannii, even better than common antibiotics. Moreover, some of these active compounds presented anti-biofilm effect by either preventing formation or dispersing A. baumannii biofilms, and disrupting the quorum-sensing (QS) system.

Conclusion

Based on the results, essential oils (EOs) of Myrtus communis, Ziziphora tenuior, Pimenta dioica and Pimenta racemose, Eucalyptus camaldulensis, Origanum vulgare, and Mentha pulegium as well as linalool displayed promising effects against A. baumannii. However, further mechanistic, toxicological, and in vivo investigations are necessary to confirm their clinical efficacy.

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利用植物对抗鲍曼不动杆菌作为抗多药耐药细菌的有前途的武器的展望：系统综述

目的和目的多药耐药鲍曼不动杆菌是各种医院感染的主要原因，包括呼吸机相关性肺炎、菌血症、脑膜炎、尿路感染和伤口感染。因此，寻找新的化合物或治疗方法来克服这种病原体是必要的。本文系统地研究了具有抗菌和抗生物膜活性的草药成分对标准和临床分离的鲍曼不动杆菌的作用。方法在Web of Sciences、PubMed、Medline和Scopus四个主要的学术数据库中检索截至2023年3月18日发表的论文。这项研究遵循了Cochrane手册中列出的七个程序。我们使用了多个关键词来搜索论文，包括“A”。鲍曼尼菌与“草药”或“植物化合物”，以及“生物膜”或“抗菌”或“抗微生物”的组合。结果共综述了29篇研究133种植物对鲍曼不动杆菌影响的文献。本研究采用微/大肉汤稀释法和/或琼脂孔/圆盘扩散法评价中药衍生化合物的抗菌性能。几种化合物对多重耐药鲍曼不动杆菌具有明显的抗菌和杀菌作用，甚至优于普通抗生素。此外，部分活性化合物通过阻止鲍曼不动杆菌生物膜的形成或分散，破坏群体感应（QS）系统而具有抗生物膜作用。结论综上所述，桃金娘精油、青椒精油、洋红、总状洋红精油、桉树精油、芫荽精油、薄荷精油和芳樟醇精油对鲍曼不动鲍曼不动鲍曼不动鲍曼不动鲍曼不动鲍曼不动鲍曼不动鲍曼不动鲍曼。然而，进一步的机制，毒理学和体内研究是必要的，以确认其临床疗效。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Herbal Medicine INTEGRATIVE & COMPLEMENTARY MEDICINE-

CiteScore

3.90

自引率

0.00%

发文量

期刊介绍： The Journal of Herbal Medicine, the official journal of the National Institute of Medical Herbalists, is a peer reviewed journal which aims to serve its readers as an authoritative resource on the profession and practice of herbal medicine. The content areas of the journal reflect the interests of Medical Herbalists and other health professionals interested in the clinical and professional application of botanical medicines. The objective is to strengthen the research and educational base of herbal medicine with research papers in the form of case studies, original research articles and reviews, monographs, clinical trials and relevant in vitro studies. It also publishes policy statements, opinion pieces, book reviews, conference proceedings and profession related information such as pharmacovigilance reports providing an information source for not only the Herbal Practitioner but any Health professional with an interest in phytotherapy.