Microtubule nucleation: How the NEDD1:MZT1:GCP3 trio captures the γ-TuRC.

IF 7.4 1区生物学 Q1 CELL BIOLOGY

Journal of Cell Biology Pub Date : 2025-07-15 DOI:10.1083/jcb.202506019

Clémence Paumier,Cécile Sauvanet,Benoît Gigant

引用次数: 0

Abstract

In the cell, microtubules are nucleated by the γ-tubulin ring complex (γ-TuRC). In this issue, Muñoz-Hernández, Xu, and colleagues (https://doi.org/10.1083/jcb.202410206) combine cryo-EM and AlphaFold modeling to detail how the NEDD1 protein recruits the γ-TuRC to microtubule-organizing centers.

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微管成核：NEDD1:MZT1:GCP3三人组如何捕获γ-TuRC。

在细胞中，微管由γ-微管蛋白环复合物（γ-TuRC）成核。在这一期中，Muñoz-Hernández， Xu和同事（https://doi.org/10.1083/jcb.202410206）结合冷冻电镜和AlphaFold模型详细描述了NEDD1蛋白如何将γ-TuRC招募到微管组织中心。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Cell Biology 生物-细胞生物学

CiteScore

12.60

自引率

2.60%

发文量

213

审稿时长

1 months

期刊介绍： The Journal of Cell Biology (JCB) is a comprehensive journal dedicated to publishing original discoveries across all realms of cell biology. We invite papers presenting novel cellular or molecular advancements in various domains of basic cell biology, along with applied cell biology research in diverse systems such as immunology, neurobiology, metabolism, virology, developmental biology, and plant biology. We enthusiastically welcome submissions showcasing significant findings of interest to cell biologists, irrespective of the experimental approach.