The Correlation Between Zinc Intake and Superoxide Dismutase Activity with Cognitive Function in the Elderly.

Q3 Medicine

Sultan Qaboos University Medical Journal Pub Date : 2025-05-02 eCollection Date: 2025-01-01 DOI:10.18295/2075-0528.2866

Rima Khuzaimah, Fiastuti Witjaksono, Novi Silvia Hardiany

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Abstract

Objectives: This study aimed to analyse the correlation between zinc intake and superoxide dismutase (SOD) with cognitive function in the elderly. Thus, the role of zinc as a structural component of SOD, along with SOD's contribution to cognitive function, can be established.

Methods: This cross-sectional study was conducted at Panti Sosial Tresna Wredha Budi Mulia 1 in Jakarta, Indonesia, from July to September 2024. Elderly men and women were included. Zinc intake was assessed using the Semi-Quantitative Food Frequency Questionnaire, while plasma SOD activity was measured by spectrophotometer. Cognitive function was assessed using the Montreal Cognitive Assessment-Indonesia version. Data were analysed using bivariate testing and multivariate linear regression.

Results: A total of 85 subjects were included with a median age of 69 years (61.2% were female and 38.8% male). The majority (72.9%) had primary-level education and 87.1% had chronic diseases. The mean physical activity score was 75.4 ± 39.8, the mean body mass index was 21.8 ± 3.9 kg/m² and the median daily calorie intake was 1,927.8 kcal/day (range: 1,341.7-2,167.0 kcal/day). No correlation was found between zinc intake and cognitive function. However, a significant correlation (P = 0.006, r = 0.296) was observed between SOD levels and cognitive function, with multivariate analysis indicating that gender, education and SOD accounted for 15.9% of the variance in cognitive function.

Conclusion: This study found no significant correlation between zinc intake and cognitive function. However, SOD activity were significantly correlated with cognitive function in the elderly.

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老年人锌摄入量、超氧化物歧化酶活性与认知功能的关系。

目的：分析老年人锌摄入量与超氧化物歧化酶（SOD）与认知功能的关系。因此，锌作为SOD的结构成分的作用，以及SOD对认知功能的贡献，可以确定。方法：本横断面研究于2024年7 - 9月在印度尼西亚雅加达的Panti social treresna Wredha Budi Mulia 1进行。老年人也包括在内。用半定量食物频率问卷评估锌摄入量，用分光光度计测定血浆SOD活性。认知功能评估采用蒙特利尔认知评估-印度尼西亚版。数据分析采用双变量检验和多元线性回归。结果：共纳入85例受试者，中位年龄69岁（女性61.2%，男性38.8%）。大多数人（72.9%）受过初级教育，87.1%患有慢性病。平均身体活动得分为75.4±39.8，平均体重指数为21.8±3.9 kg/m2，平均每日卡路里摄入量为1,927.8 kcal/天（范围：1,341.7-2,167.0 kcal/天）。锌摄入量与认知功能之间没有相关性。然而，SOD水平与认知功能之间存在显著相关（P = 0.006, r = 0.296），多因素分析表明，性别、教育程度和SOD占认知功能方差的15.9%。结论：本研究未发现锌摄入量与认知功能之间存在显著相关性。然而，SOD活性与老年人认知功能显著相关。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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