{"title":"Neuro-immune interactions in memory.","authors":"E Stewart, T J Ryan","doi":"10.1016/j.nlm.2025.108077","DOIUrl":null,"url":null,"abstract":"<p><p>Responding appropriately to both internal and external factors to maintain homeostasis is key to survival in the dynamic environment we live in. Memory a is highly adaptive brain function which enables organisms to interact efficiently with their environment by processing and storing perceptual inputs. Memory shapes behaviour in the present based on past experiences. These experiences are defined by both external environmental cues and internal signals (physiological state) and this requires integration and feedback between central and peripheral systems. The immune system is a key physiological system that works to protect against pathogens and maintain homeostasis and can mediate behavioural changes through communication with the brain. Here we review the dynamic relationship between memory and the immune system in both health and disease.</p>","PeriodicalId":19102,"journal":{"name":"Neurobiology of Learning and Memory","volume":" ","pages":"108077"},"PeriodicalIF":2.2000,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Neurobiology of Learning and Memory","FirstCategoryId":"102","ListUrlMain":"https://doi.org/10.1016/j.nlm.2025.108077","RegionNum":4,"RegionCategory":"心理学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q3","JCRName":"BEHAVIORAL SCIENCES","Score":null,"Total":0}
引用次数: 0
Abstract
Responding appropriately to both internal and external factors to maintain homeostasis is key to survival in the dynamic environment we live in. Memory a is highly adaptive brain function which enables organisms to interact efficiently with their environment by processing and storing perceptual inputs. Memory shapes behaviour in the present based on past experiences. These experiences are defined by both external environmental cues and internal signals (physiological state) and this requires integration and feedback between central and peripheral systems. The immune system is a key physiological system that works to protect against pathogens and maintain homeostasis and can mediate behavioural changes through communication with the brain. Here we review the dynamic relationship between memory and the immune system in both health and disease.
期刊介绍：
Neurobiology of Learning and Memory publishes articles examining the neurobiological mechanisms underlying learning and memory at all levels of analysis ranging from molecular biology to synaptic and neural plasticity and behavior. We are especially interested in manuscripts that examine the neural circuits and molecular mechanisms underlying learning, memory and plasticity in both experimental animals and human subjects.
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