A Bidirectional Mendelian Randomization Study of Causal Relationships Between Migraine and White-Matter Structural Connectivity.

IF 2.5 3区医学 Q2 CLINICAL NEUROLOGY

Journal of Pain Research Pub Date : 2025-07-09 eCollection Date: 2025-01-01 DOI:10.2147/JPR.S521100

Dan Tong, Xinyue Zhang, Zhiyong Xiao, Supattra Taothong, Prapawee Teeravarunyou, Wanxia Wu, Sai Wu, Nuo Chen, Siyuan Tao, Jun Zhou, Qian Song, Fanrong Liang, Zhengjie Li

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引用次数: 0

Abstract

Objective: This study aims to investigate the potential causal relationship between migraine and white matter (WM) structural connectivity using genetic data and the Mendelian randomization (MR) analyses method.

Methods: Genome-wide association study (GWAS) summary statistics for migraine (48,975 cases/540,381 controls) and 206 WM structural connectivity related imaging-derived phenotypes (IDPs) (26,333 samples) were collected. Based on instrumental variables (IVs) selected from the GWAS summary statistics, the bidirectional two-sample MR analyses were conducted to infer bidirectional causal associations between migraine and WM structural connectivity. The inverse variance-weighted (IVW) method served as the primary approach for analyzing causality.

Results: In the forward MR analysis, it was found that migraine had a significant effect on right hemisphere somatomotor network to amygdala WM structural connectivity (IVW-derived β = 0.11, 95% CI = [0.04, 0.17], p = 1.02e-03, FDR p = 0.04). While in the reverse MR analysis, no causal link was detected between WM structural connectivity and migraine.

Conclusion: This study provides genetic evidences for a causal relationship between migraine and WM structural connectivity. These findings provide new perspectives for the understanding of neuropathology and symptomatology in migraine and might provide a potential therapeutic target for future migraine treatment research.

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偏头痛与白质结构连通性因果关系的双向孟德尔随机研究。

目的：本研究旨在利用遗传数据和孟德尔随机化（MR）分析方法探讨偏头痛与白质（WM）结构连通性之间的潜在因果关系。方法：收集偏头痛（48,975例/540,381例对照）和206个WM结构连接相关成像衍生表型（IDPs）（26,333个样本）的全基因组关联研究（GWAS）汇总统计数据。基于从GWAS汇总统计中选择的工具变量（IVs），进行双向双样本MR分析，以推断偏头痛与WM结构连通性之间的双向因果关系。反方差加权（IVW）法是分析因果关系的主要方法。结果：在正向MR分析中，发现偏头痛对右半球体运动网络到杏仁核WM结构连接有显著影响（ivw衍生β = 0.11, 95% CI = [0.04, 0.17], p = 1.002 -03, FDR p = 0.04）。而在反向MR分析中，没有发现WM结构连通性与偏头痛之间的因果关系。结论：本研究为偏头痛与WM结构连通性之间的因果关系提供了遗传学证据。这些发现为认识偏头痛的神经病理学和症状学提供了新的视角，并可能为未来偏头痛的治疗研究提供潜在的治疗靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Pain Research CLINICAL NEUROLOGY-

CiteScore

4.50

自引率

3.70%

发文量

411

审稿时长

16 weeks

期刊介绍： Journal of Pain Research is an international, peer-reviewed, open access journal that welcomes laboratory and clinical findings in the fields of pain research and the prevention and management of pain. Original research, reviews, symposium reports, hypothesis formation and commentaries are all considered for publication. Additionally, the journal now welcomes the submission of pain-policy-related editorials and commentaries, particularly in regard to ethical, regulatory, forensic, and other legal issues in pain medicine, and to the education of pain practitioners and researchers.