Immune cells in liver regeneration: Current evidence and potential clinical targets.

IF 2.9 4区医学 Q2 IMMUNOLOGY

International Reviews of Immunology Pub Date : 2025-07-14 DOI:10.1080/08830185.2025.2531820

Hollie F Moore, Saba Usmani, Saied Froghi, Hasan Rashidi, Alberto Quaglia, Barry Fuller, Brian R Davidson

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引用次数: 0

Abstract

The livers' ability to regenerate after injury has attracted the investigation of possible therapeutic targets for liver disease. Cells of the immune system are considered fundamental for the initiation, propagation, and termination of liver regeneration as they produce essential signaling molecules, such as cytokines, chemokines, and growth factors. Previous evidence mainly focused on macrophage involvement in liver regeneration, namely Kupffer cells which secrete mitogenic cytokines. However, recent evidence has implicated other immune cell subsets in liver regeneration including platelets, the complement system, dendritic cells, granulocytes, and innate and adaptive lymphocytes. The concurrent function of different immune cell subsets highlights functional redundancies between immune cells and the temporospatial dynamics of liver regeneration. In this review, we discuss our understanding of the role of immune cells in liver regeneration, recent advances and cellular targets identified for clinical therapy over the past decade.

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肝再生中的免疫细胞：目前的证据和潜在的临床靶点。

肝脏损伤后的再生能力吸引了肝脏疾病可能治疗靶点的研究。免疫系统的细胞被认为是肝脏再生的起始、繁殖和终止的基础，因为它们产生必要的信号分子，如细胞因子、趋化因子和生长因子。先前的证据主要集中在巨噬细胞参与肝脏再生，即分泌有丝分裂细胞因子的库普弗细胞。然而，最近的证据表明，肝再生中的其他免疫细胞亚群包括血小板、补体系统、树突状细胞、粒细胞、先天和适应性淋巴细胞。不同免疫细胞亚群的并发功能突出了免疫细胞之间的功能冗余和肝脏再生的时空动态。在这篇综述中，我们讨论了我们对免疫细胞在肝脏再生中的作用的理解，最近的进展和在过去十年中确定的临床治疗的细胞靶点。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International Reviews of Immunology 医学-免疫学

CiteScore

11.00

自引率

4.00%

发文量

期刊介绍： This review journal provides the most current information on basic and translational research in immunology and related fields. In addition to invited reviews, the journal accepts for publication articles and editorials on relevant topics proposed by contributors. Each issue of International Reviews of Immunology contains both solicited and unsolicited review articles, editorials, and ''In-this-Issue'' highlights. The journal also hosts reviews that position the authors'' original work relative to advances in a given field, bridging the gap between annual reviews and the original research articles. This review series is relevant to all immunologists, molecular biologists, microbiologists, translational scientists, industry researchers, and physicians who work in basic and clinical immunology, inflammatory and allergic diseases, vaccines, and additional topics relevant to medical research and drug development that connect immunology to disciplines such as oncology, cardiovascular disease, and metabolic disorders. Covered in International Reviews of Immunology: Basic and developmental immunology (innate and adaptive immunity; inflammation; and tumor and microbial immunology); Clinical research (mechanisms of disease in man pertaining to infectious diseases, autoimmunity, allergy, oncology / immunology); and Translational research (relevant to biomarkers, diagnostics, vaccines, and drug development).