The Senescence Associated Secretory Phenotype, a key marker of cellular senescence, is elevated in depression and moderated by sex.

IF 4.6 2区医学 Q1 GERIATRICS & GERONTOLOGY

International psychogeriatrics Pub Date : 2025-07-12 DOI:10.1016/j.inpsyc.2025.100113

Nishika Navrange, Ana Paula Mendes-Silva, Charles F Reynolds, Julie Wetherell, Benoit Mulsant, Mary C Kimmel, Eric J Lenze, Breno Satler Diniz

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引用次数: 0

Abstract

Objective: Studies have found elevation in a key biomarker of aging (the senescence-associated secretory phenotype (SASP) index) in depression. We investigated whether sex moderates the association between the SASP and major depression in older adults.

Methods: We included 423 older adults in a current major depressive episode and 140 adults with no history of depression. We measured the plasma levels of SASP biomarkers using multiplex immunoassays. The interaction effect between sex, depression diagnosis, and senescence markers were analyzed by general linear models, adjusted for confounding variables.

Results: Individuals with depression had a higher SASP index than the healthy comparison group (t-test= -3.902, p < 0.001). We found a significant diagnosis by sex interaction (F= 9.112, df= 1540, p = 0.003), with males with depression having the highest SASP index levels (F=20.678, df=1540, p < 0.001).

Conclusions: In older adults, sex plays a significant role in senescence-related changes in depression. A higher senescence burden in males with depression may be an indicator of greater vulnerability to accelerated biological aging and a marker of elevated risk of adverse outcomes in this sex.

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衰老相关分泌表型是细胞衰老的关键标志，在抑郁症中升高，并受性别调节。

目的：研究发现抑郁症中衰老的关键生物标志物（衰老相关分泌表型（SASP）指数）升高。我们调查了性别是否会缓和老年人SASP与重度抑郁症之间的关系。方法：我们纳入了423名目前有重度抑郁发作的老年人和140名没有抑郁史的成年人。我们使用多重免疫分析法测量血浆中SASP生物标志物的水平。性别、抑郁诊断和衰老标志物之间的相互作用效应通过一般线性模型进行分析，并对混杂变量进行调整。结果：抑郁症患者的SASP指数高于健康对照组（t检验= -3.902,p）。结论：在老年人中，性别在抑郁的衰老相关变化中起着重要作用。男性抑郁症患者较高的衰老负担可能是更容易加速生物衰老的一个指标，也是该性别不良后果风险升高的一个标志。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

International psychogeriatrics 医学-精神病学

CiteScore

9.10

自引率

8.60%

发文量

217

审稿时长

3-6 weeks

期刊介绍： A highly respected, multidisciplinary journal, International Psychogeriatrics publishes high quality original research papers in the field of psychogeriatrics. The journal aims to be the leading peer reviewed journal dealing with all aspects of the mental health of older people throughout the world. Circulated to over 1,000 members of the International Psychogeriatric Association, International Psychogeriatrics also features important editorials, provocative debates, literature reviews, book reviews and letters to the editor.