Understanding amblyopia from the perspective of neurovascular units: changes in the retina and brain.

IF 4.6 2区生物学 Q2 CELL BIOLOGY

Frontiers in Cell and Developmental Biology Pub Date : 2025-06-27 eCollection Date: 2025-01-01 DOI:10.3389/fcell.2025.1590009

Lin Zhang, Yaqi Zhao, Xiaolu Shi, Fan Wu, Yi Shen

引用次数: 0

Abstract

As a developmental vision disorder, amblyopia has traditionally been studied with a focus on neurons. However, the neurovascular unit (NVU), a dynamic functional complex of neurons, blood vessels, and glial cells, has recently been implicated in amblyopia. This review systematically discusses the pathological changes and functional interactions of the NVU in retina and brain in amblyopia patients and experimental models, providing a new perspective for clinical intervention.

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从神经血管单位的角度理解弱视：视网膜和大脑的变化。

弱视作为一种发育性视觉障碍，传统上的研究重点是神经元。然而，神经血管单元（NVU），神经元、血管和神经胶质细胞的动态功能复合体，最近被认为与弱视有关。本文系统探讨了弱视患者视网膜和脑内NVU的病理变化和功能相互作用，并建立了实验模型，为临床干预提供了新的视角。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Cell and Developmental Biology Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

9.70

自引率

3.60%

发文量

2531

审稿时长

12 weeks

期刊介绍： Frontiers in Cell and Developmental Biology is a broad-scope, interdisciplinary open-access journal, focusing on the fundamental processes of life, led by Prof Amanda Fisher and supported by a geographically diverse, high-quality editorial board. The journal welcomes submissions on a wide spectrum of cell and developmental biology, covering intracellular and extracellular dynamics, with sections focusing on signaling, adhesion, migration, cell death and survival and membrane trafficking. Additionally, the journal offers sections dedicated to the cutting edge of fundamental and translational research in molecular medicine and stem cell biology. With a collaborative, rigorous and transparent peer-review, the journal produces the highest scientific quality in both fundamental and applied research, and advanced article level metrics measure the real-time impact and influence of each publication.