Research progress of ECT2 and RhoA-related signaling pathways in gynecological tumors.

IF 4.6 2区生物学 Q2 CELL BIOLOGY

Frontiers in Cell and Developmental Biology Pub Date : 2025-06-27 eCollection Date: 2025-01-01 DOI:10.3389/fcell.2025.1602649

Liying Sheng, Meili Liang, Yueli Wang, Zhimei Zhou, Yajing Xie, Yumin Ke, Zhuna Wu

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Abstract

Epithelial Cell Transformation Factor 2 (ECT2) is highly expressed in a variety of cancers, including gynecological tumors. The mislocalization of ECT2 can abnormally activate Ras homolog family member A (RhoA) in the Ras homolog gene family (Rho) Guanine nucleotide Exchange Factor (GEF) family. Activated RhoA binds to Rho-associated protein kinase (ROCK), phosphorylates various target proteins, triggers a cascade reaction, regulates the functions of downstream proteins, and thereby plays an important role in the occurrence and development of tumors. This article reviews the roles of ECT2 and RhoA/ROCK signaling pathways in ovarian cancer, cervical cancer, and endometrial cancer, and summarizes and discusses the research progress of downstream molecules, transduction pathways, and mechanisms related to them. Through comprehensive analysis and summary of the current research results, it is revealed that the ECT2/RhoA/ROCK signaling pathway and related crosstalk pathways play an important role in the occurrence, development, and metastasis of gynecological tumors. This article aims to provide a basis for related research and offer relevant references for the treatment of gynecological tumors in the future.

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妇科肿瘤中ECT2和rhoa相关信号通路的研究进展。

上皮细胞转化因子2 （Epithelial Cell Transformation Factor 2, ECT2）在多种癌症中高表达，包括妇科肿瘤。ECT2的错位可异常激活Ras同源基因家族（Rho）鸟嘌呤核苷酸交换因子（GEF）家族中的Ras同源家族成员A （RhoA）。活化的RhoA与RhoA相关蛋白激酶（ROCK）结合，磷酸化各种靶蛋白，引发级联反应，调节下游蛋白的功能，从而在肿瘤的发生发展中发挥重要作用。本文综述了ECT2和RhoA/ROCK信号通路在卵巢癌、宫颈癌和子宫内膜癌中的作用，并对其下游分子、转导通路及其相关机制的研究进展进行了总结和讨论。通过对现有研究成果的综合分析和总结，揭示了ECT2/RhoA/ROCK信号通路及相关串扰通路在妇科肿瘤的发生、发展和转移中发挥着重要作用。本文旨在为相关研究提供依据，并为今后妇科肿瘤的治疗提供相关参考。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Cell and Developmental Biology Biochemistry, Genetics and Molecular Biology-Cell Biology

CiteScore

9.70

自引率

3.60%

发文量

2531

审稿时长

12 weeks

期刊介绍： Frontiers in Cell and Developmental Biology is a broad-scope, interdisciplinary open-access journal, focusing on the fundamental processes of life, led by Prof Amanda Fisher and supported by a geographically diverse, high-quality editorial board. The journal welcomes submissions on a wide spectrum of cell and developmental biology, covering intracellular and extracellular dynamics, with sections focusing on signaling, adhesion, migration, cell death and survival and membrane trafficking. Additionally, the journal offers sections dedicated to the cutting edge of fundamental and translational research in molecular medicine and stem cell biology. With a collaborative, rigorous and transparent peer-review, the journal produces the highest scientific quality in both fundamental and applied research, and advanced article level metrics measure the real-time impact and influence of each publication.