Prevalent vertebral fractures and the diabetic bone paradox in women who sustain a hip fracture: a cross-sectional study.

IF 3.4 3区 医学 Q1 REHABILITATION
Marco Di Monaco, Carlotta Castiglioni, Francesca Bardesono, Marco A Minetto, Chiara Busso, Giuseppe Massazza
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引用次数: 0

Abstract

Background: Patients with type 2 diabetes mellitus (T2DM) have enhanced fracture risk despite high bone mineral density (BMD), a phenomenon known as the diabetic bone paradox. Consistently with the paradox, hip fractures occur at higher BMD in women with T2DM than in controls. However, no studies have addressed BMD in women with T2DM who have prevalent vertebral fractures at the time of their first hip fracture.

Aim: The aim of this study was to test the hypothesis that BMD levels could be higher in the hip-fracture women with versus without T2DM in the absence but not in the presence of prevalent vertebral fractures.

Design: This was a cross-sectional study.

Setting: The research took place in a rehabilitation ward.

Population: The study involved women who were undergoing inpatient rehabilitation following a subacute hip fracture.

Methods: We investigated hip-fracture women with and without prevalent vertebral fractures, consecutively admitted to our rehabilitation ward. At a median of 19 days after the hip fracture we assessed femoral BMD by dual-energy X-ray absorptiometry and prevalent vertebral fractures by X-ray examination.

Results: The study sample included 504 women. One hundred eighty-five of the 504 had no vertebral fractures whereas 319 had at least one spine fracture. The 185 women without vertebral fractures had BMD higher in the presence (N.=29) than in the absence (N.=156) of T2DM (mean T-score difference was 0.67, 95% confidence interval (CI) from 0.31 to 1.03, P<0.001). After adjustment for 8 potential confounders, the odds ratio to have densitometric osteoporosis for a woman without T2DM was 3.21 (95% CI from 1.10 to 9.33, P=0.032). On the contrary, in the 319 women with vertebral fractures T2DM was not associated with BMD.

Conclusions: At the time of an original hip fracture, we found a BMD gap between women with and without T2DM in the absence but not in the presence of prevalent vertebral fractures.

Clinical rehabilitation impact: Adjustments of fracture risk calculation in T2DM have been authoritatively suggested, because high BMD levels may falsely lead to risk underestimation. Our data suggests that no adjustments may be needed for the risk estimation in patients with prevalent vertebral fractures. Further data from longitudinal studies are needed to define the role of both prevalent vertebral fractures and BMD in fracture risk of patients with T2DM.

Abstract Image

Abstract Image

流行椎体骨折和糖尿病性骨悖论的妇女谁维持髋部骨折:横断面研究。
背景:2型糖尿病(T2DM)患者尽管骨密度(BMD)较高,但骨折风险增加,这一现象被称为糖尿病骨悖论。与矛盾一致的是,2型糖尿病患者髋部骨折的骨密度高于对照组。然而,没有研究涉及在第一次髋部骨折时有椎体骨折的2型糖尿病女性的骨密度。目的:本研究的目的是验证这样一种假设,即在没有普遍的椎体骨折的情况下,伴有2型糖尿病的髋部骨折女性的骨密度水平可能高于未伴有2型糖尿病的女性。设计:这是一项横断面研究。环境:研究在康复病房进行。人群:该研究涉及亚急性髋部骨折后正在住院康复的妇女。方法:我们对连续入住康复病房的髋部骨折伴和不伴椎体骨折的女性进行调查。在髋部骨折后中位19天,我们通过双能x线骨密度仪评估股骨骨密度,并通过x线检查评估椎骨骨折发生率。结果:研究样本包括504名女性。504例患者中有185例没有椎体骨折,而319例至少有一次脊柱骨折。185名无椎体骨折的女性,其骨密度在T2DM存在时(n =29)高于无T2DM存在时(n =156)(平均t评分差为0.67,95%可信区间(CI)从0.31到1.03)。结论:在原发髋部骨折时,我们发现T2DM女性与非T2DM女性在无椎体骨折存在时骨密度存在差距,但在普遍存在椎体骨折时没有。临床康复影响:权威建议调整T2DM骨折风险计算,因为高BMD水平可能错误地导致风险低估。我们的数据表明,对于常见椎体骨折患者的风险估计,不需要进行调整。需要进一步的纵向研究数据来确定普遍的椎体骨折和骨密度在T2DM患者骨折风险中的作用。
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来源期刊
CiteScore
8.50
自引率
4.40%
发文量
162
审稿时长
6-12 weeks
期刊介绍: The European Journal of Physical and Rehabilitation Medicine publishes papers of clinical interest in physical and rehabilitation medicine.
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