The Prognostic Value of Combined Systemic Immune-Inflammatory Index (SII) and Prognostic Nutritional Index (PNI) in Solid Tumor.

IF 2.5 4区医学 Q3 ONCOLOGY

Cancer Management and Research Pub Date : 2025-07-08 eCollection Date: 2025-01-01 DOI:10.2147/CMAR.S523419

Yan Zhang, Min Tang, Qian-Hui Gu, Li-Na Zhou, Min-Bin Chen

{"title":"The Prognostic Value of Combined Systemic Immune-Inflammatory Index (SII) and Prognostic Nutritional Index (PNI) in Solid Tumor.","authors":"Yan Zhang, Min Tang, Qian-Hui Gu, Li-Na Zhou, Min-Bin Chen","doi":"10.2147/CMAR.S523419","DOIUrl":null,"url":null,"abstract":"Background: Inflammation and nutrition status were the essential factors for cancer initiation and progression. Previous studies have confirmed systemic immune-inflammatory index (SII) and prognostic nutritional index (PNI) could predict the prognosis of cancer patients. The aim of this study was to evaluate the pre-treatment SII and PNI in predicting outcomes in different cancers.Methods: The retrospective study included 508 cancer cases diagnosed between June 2013 and June 2022. The pre-treatment SII and PNI were calculated from peripheral blood samples, and the cutoff value was determined by receiver operating characteristic (ROC). The association of SII, PNI with clinicopathological characters and prognosis were assessed by Cox regression and Kaplan-Meier methods.Results: The ideal preoperative SII and PNI cutoff values were 792.0 and 49.825, respectively. High SII group as well as low PNI group had worse prognosis. Patients satisfied both high SII and low PNI had the lowest overall survival (OS) rate (p < 0.001). Multivariable Cox regression analysis identified that the tumor stage (p < 0.001), BMI (p = 0.042), SII (p = 0.001) and AGR (p = 0.047) were independently prognostic markers for OS.Conclusion: High level of pretreatment SII may be an independent prognostic factor for cancer patients. Patients with both high SII and low PNI had the worst prognosis.","PeriodicalId":9479,"journal":{"name":"Cancer Management and Research","volume":"17 ","pages":"1351-1359"},"PeriodicalIF":2.5000,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12255326/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cancer Management and Research","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.2147/CMAR.S523419","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/1/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"ONCOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background: Inflammation and nutrition status were the essential factors for cancer initiation and progression. Previous studies have confirmed systemic immune-inflammatory index (SII) and prognostic nutritional index (PNI) could predict the prognosis of cancer patients. The aim of this study was to evaluate the pre-treatment SII and PNI in predicting outcomes in different cancers.

Methods: The retrospective study included 508 cancer cases diagnosed between June 2013 and June 2022. The pre-treatment SII and PNI were calculated from peripheral blood samples, and the cutoff value was determined by receiver operating characteristic (ROC). The association of SII, PNI with clinicopathological characters and prognosis were assessed by Cox regression and Kaplan-Meier methods.

Results: The ideal preoperative SII and PNI cutoff values were 792.0 and 49.825, respectively. High SII group as well as low PNI group had worse prognosis. Patients satisfied both high SII and low PNI had the lowest overall survival (OS) rate (p < 0.001). Multivariable Cox regression analysis identified that the tumor stage (p < 0.001), BMI (p = 0.042), SII (p = 0.001) and AGR (p = 0.047) were independently prognostic markers for OS.

Conclusion: High level of pretreatment SII may be an independent prognostic factor for cancer patients. Patients with both high SII and low PNI had the worst prognosis.

查看原文本刊更多论文

综合全身免疫-炎症指数（SII）和预后营养指数（PNI）在实体瘤中的预后价值。

背景：炎症和营养状况是癌症发生和发展的重要因素。既往研究证实系统性免疫炎症指数（SII）和预后营养指数（PNI）可以预测肿瘤患者的预后。本研究的目的是评估治疗前SII和PNI在预测不同癌症预后方面的作用。方法：回顾性研究纳入2013年6月至2022年6月诊断的508例癌症病例。根据外周血样本计算预处理前SII和PNI，并根据受试者工作特征（ROC）确定截断值。采用Cox回归和Kaplan-Meier方法评价SII、PNI与临床病理特征及预后的关系。结果：理想的术前SII和PNI临界值分别为792.0和49.825。高SII组和低PNI组预后较差。同时满足高SII和低PNI的患者总生存率（OS）最低（p < 0.001）。多变量Cox回归分析发现，肿瘤分期（p < 0.001）、BMI （p = 0.042）、SII （p = 0.001）和AGR （p = 0.047）是OS的独立预后指标。结论：高水平的SII预处理可能是癌症患者预后的一个独立因素。高SII和低PNI的患者预后最差。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Cancer Management and Research Medicine-Oncology

CiteScore

7.40

自引率

0.00%

发文量

448

审稿时长

16 weeks

期刊介绍： Cancer Management and Research is an international, peer reviewed, open access journal focusing on cancer research and the optimal use of preventative and integrated treatment interventions to achieve improved outcomes, enhanced survival, and quality of life for cancer patients. Specific topics covered in the journal include: ◦Epidemiology, detection and screening ◦Cellular research and biomarkers ◦Identification of biotargets and agents with novel mechanisms of action ◦Optimal clinical use of existing anticancer agents, including combination therapies ◦Radiation and surgery ◦Palliative care ◦Patient adherence, quality of life, satisfaction The journal welcomes submitted papers covering original research, basic science, clinical & epidemiological studies, reviews & evaluations, guidelines, expert opinion and commentary, and case series that shed novel insights on a disease or disease subtype.