Choline–geranate (CAGE) ionic liquids potentiate the anticancer activity of platinum-based drugs†

IF 4.2 2区化学 Q2 CHEMISTRY, MULTIDISCIPLINARY

Chemical Communications Pub Date : 2025-07-11 DOI:10.1039/d5cc02226f

Marta Costa Verdugo , Giulia Sierri , Laura Hernandez-Fernandez , Elena Formoso , José I. Miranda , Francesco Saverio Sica , Alejandro H. Orrego , Alba González , Elixabete Rezabal , Francesca Re , Luca Salassa

引用次数: 0

Abstract

The influence of choline and geranic acid-based ionic liquids (CAGE ILs) on the anticancer activity of selected Pt(ii) and Pt(iv) complexes was investigated. All complexes exhibited appreciable solubility in CAGE ILs, with Pt(ii) complexes and undergoing immediate ligand substitution. In contrast, the hydrophobic derivative demonstrated remarkable stability for up to 48 hours. ¹⁹F–¹H HOESY NMR analysis revealed that localized within the hydrophobic regions of CAGE 1 : 2 (choline:geranate). When tested in U87-MG glioblastoma cells, CAGE ILs enhanced the anticancer activity of the Pt complexes. Notably, complex exhibited a significant increase in cytotoxicity, nearly completely reducing cell viability when formulated with CAGE IL.

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胆碱-geranate （CAGE）离子液体增强了铂类药物的抗癌活性。

研究了胆碱和有机酸离子液体（CAGE ILs）对选定的Pt（II）和Pt（IV）配合物抗癌活性的影响。所有配合物在CAGE il中都表现出明显的溶解度，其中Pt（II）配合物2和4发生了直接的配体取代。相比之下，疏水衍生物3在长达48小时的时间内表现出显著的稳定性。19F-1H HOESY NMR分析显示，其中3个位于CAGE 1:1（胆碱：胆酸酯）的疏水区域。在U87-MG胶质母细胞瘤细胞中，CAGE il增强了Pt复合物的抗癌活性。值得注意的是，当与CAGE IL配制时，复合物3表现出显著的细胞毒性，几乎完全降低了细胞活力。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Chemical Communications 化学-化学综合

CiteScore

8.60

自引率

4.10%

发文量

2705

审稿时长

1.4 months

期刊介绍： ChemComm (Chemical Communications) is renowned as the fastest publisher of articles providing information on new avenues of research, drawn from all the world''s major areas of chemical research.