Cognitive impairment and dementia in Latin American individuals with parkinsonism and Parkinson's disease: A 10/66 Dementia Research Group study

IF 13 1区医学 Q1 CLINICAL NEUROLOGY

Alzheimer's & Dementia Pub Date : 2025-07-14 DOI:10.1002/alz.70371

Nusrat Khan, Micaela María Arruabarrena, Dani J. Kim, Miao Jiang, Juan J. Llibre-Rodriguez, Ana M. Rodriguez-Salgado, Issac Acosta, Ana Luisa Sosa, Daisy Acosta, Ivonne Z. Jimenez-Velasquez, Mariella Guerra, Aquiles Salas, Ricardo López-Contreras, Dhara Santana, Joel Solorzano, Christina Jeyachandran, Heike Hesse, Caroline Tanner, Matthew Prina, Jorge J. Llibre-Guerra

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引用次数: 0

Abstract

INTRODUCTION

This study aimed to determine the associations between parkinsonism and Parkinson's disease (PD) with cognitive impairment and dementia in a multi-country cohort in Latin America, using data from the 10/66 Dementia Research Group.

METHODS

This population-based prospective cohort study was conducted in six Latin American countries, including 11,321 participants 65 years of age or older living in urban and rural areas.

RESULTS

At baseline, the prevalence of cognitive impairment in people with parkinsonism and PD was 33% and 26%, respectively. Parkinsonism (odds ratio [OR] 2.2 [95% confidence interval [CI] 1.9–2.6] and PD (OR 1.9 [95% CI 1.4–2.4]) were individually associated with baseline cognitive impairment and incident dementia. The pooled sub-hazard ratios for dementia in fixed-effect meta-analysis were 1.5 (95% CI 1.2–1.9) for parkinsonism and 1.5 (95% CI 1.0–2.2) for PD.

DISCUSSION

Parkinsonism and PD were cross-sectionally associated with cognitive impairment and prospectively associated with incident dementia. These findings underscore the importance of routine screening for cognitive impairment in individuals with parkinsonism and PD, to facilitate early detection and intervention strategies that mitigate adverse outcomes.

Highlights

The present study is one of the first longitudinal investigations into the association of parkinsonism and Parkinson's disease (PD) with cognitive impairment and dementia incidence in Latin America.
Parkinsonism and PD showed strong cross-sectional associations with cognitive impairment, with consistent estimates across countries, independent of demographic factors.
Parkinsonism and PD were linked to a significantly higher incidence of dementia over a 4-year follow-up period.
Findings emphasize the need for routine cognitive screening in Parkinsonism and PD.

Abstract Image

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拉丁美洲帕金森和帕金森病患者的认知障碍和痴呆：一项10/66痴呆研究小组的研究

本研究旨在在拉丁美洲的一个多国队列中确定帕金森病和帕金森病（PD）与认知障碍和痴呆之间的关系，使用来自10/66痴呆研究小组的数据。方法：这项基于人群的前瞻性队列研究在6个拉丁美洲国家进行，包括11321名年龄在65岁或以上、居住在城市和农村地区的参与者。结果：在基线时，帕金森和PD患者的认知障碍患病率分别为33%和26%。帕金森病(比值比[OR] 2.2[95%可信区间[CI] 1.9 - 2.6]和帕金森病（比值比[OR] 1.9[95%可信区间[CI] 1.4-2.4]）分别与基线认知障碍和痴呆发生率相关。在固定效应荟萃分析中，痴呆的合并亚风险比在帕金森病中为1.5 (95% CI 1.2-1.9)，在帕金森病中为1.5 （95% CI 1.0-2.2）。帕金森病和帕金森病与认知障碍横断面相关，并与痴呆事件相关。这些发现强调了常规筛查帕金森和PD患者认知障碍的重要性，以促进早期发现和干预策略，减轻不良后果。本研究是拉丁美洲首次对帕金森病和帕金森病（PD）与认知障碍和痴呆发病率之间关系进行纵向调查的研究之一。帕金森氏症和帕金森病与认知障碍有很强的横断面关联，各国的估计一致，独立于人口因素。在4年的随访期间，帕金森病和帕金森病与痴呆的发病率显著升高有关。研究结果强调了在帕金森病和帕金森病中进行常规认知筛查的必要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Alzheimer's & Dementia 医学-临床神经学

CiteScore

14.50

自引率

5.00%

发文量

299

审稿时长

3 months

期刊介绍： Alzheimer's & Dementia is a peer-reviewed journal that aims to bridge knowledge gaps in dementia research by covering the entire spectrum, from basic science to clinical trials to social and behavioral investigations. It provides a platform for rapid communication of new findings and ideas, optimal translation of research into practical applications, increasing knowledge across diverse disciplines for early detection, diagnosis, and intervention, and identifying promising new research directions. In July 2008, Alzheimer's & Dementia was accepted for indexing by MEDLINE, recognizing its scientific merit and contribution to Alzheimer's research.