Polypept(o)ide-Based Core–Shell Bottlebrush Polymers: A Versatile Platform for Drug Encapsulation

IF 4.1 4区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Macromolecular bioscience Pub Date : 2025-07-14 DOI:10.1002/mabi.202570013

Bonan Zhao, Jingyuan Wei, Rüdiger Berger, Lin Jian, Kaloian Koynov, Heyang Zhang, Matthias Barz

引用次数: 0

Abstract

Front Cover: Cylindrical bottlebrush polymers (CBPs) enable precise control over nanoparticle properties via polymer synthesis. Here, a grafting-from approach utilizing a polylysine backbone enabled the formation of amphiphilic polypept(o)ide-based side chains by sequential NCA-ROP, which provides convenient access to core-shell CBPs. These core-shell architectures combine Dasatinib-loading and sustained release kinetics with cellular uptake and therapeutic efficacy in glioblastoma cells. More details can be found in article 2500083 by Heyang Zhang, Matthias Barz, and co-workers.

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多聚体(o)ide-Based核壳瓶刷聚合物：药物封装的通用平台

封面：圆柱形瓶刷聚合物（CBPs）能够通过聚合物合成精确控制纳米颗粒特性。在这里，利用聚赖氨酸主链的接枝方法可以通过顺序NCA-ROP形成两亲性多肽(o)基于ide的侧链，这为核-壳CBPs提供了方便。这些核壳结构结合了达沙替尼负载和缓释动力学与胶质母细胞瘤细胞摄取和治疗效果。更多细节可以在Heyang Zhang， Matthias Barz及其同事的文章2500083中找到。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Macromolecular bioscience 生物-材料科学：生物材料

CiteScore

7.90

自引率

2.20%

发文量

211

审稿时长

1.5 months

期刊介绍： Macromolecular Bioscience is a leading journal at the intersection of polymer and materials sciences with life science and medicine. With an Impact Factor of 2.895 (2018 Journal Impact Factor, Journal Citation Reports (Clarivate Analytics, 2019)), it is currently ranked among the top biomaterials and polymer journals. Macromolecular Bioscience offers an attractive mixture of high-quality Reviews, Feature Articles, Communications, and Full Papers. With average reviewing times below 30 days, publication times of 2.5 months and listing in all major indices, including Medline, Macromolecular Bioscience is the journal of choice for your best contributions at the intersection of polymer and life sciences.