Association between aqueous humor cytokines and posterior capsular opacification in patients with high myopia

IF 3.7 3区医学 Q2 BIOCHEMISTRY & MOLECULAR BIOLOGY

Cytokine Pub Date : 2025-07-14 DOI:10.1016/j.cyto.2025.156995

Lu Cheng , Shiqi Xie , Huiyi Jin , Yanyun Lv , Bijun Zhu , Haidong Zou , Baojiang Li , Peiyao Jin

{"title":"Association between aqueous humor cytokines and posterior capsular opacification in patients with high myopia","authors":"Lu Cheng , Shiqi Xie , Huiyi Jin , Yanyun Lv , Bijun Zhu , Haidong Zou , Baojiang Li , Peiyao Jin","doi":"10.1016/j.cyto.2025.156995","DOIUrl":null,"url":null,"abstract":"<div><h3>Background</h3><div>Posterior capsular opacification (PCO) remains a significant complication following cataract surgery, with an unclear pathogenesis in patients with high myopia. This study investigated the aqueous humor (AH) cytokine profile in patients with cataracts and high myopia and its relationship with the development of PCO.</div></div><div><h3>Methods</h3><div>AH samples were collected from 36 patients undergoing cataract surgery, including 18 with high myopia (axial length > 26 mm) and 18 age- and sex-matched controls. The levels of 19 PCO-associated cytokines were measured using a multiplex immunoassay, and PCO severity was assessed at 6 months postoperatively.</div></div><div><h3>Results</h3><div>Compared to controls, patients with high myopia exhibited significantly elevated levels of vascular endothelial growth factor (VEGF)-C, hepatocyte growth factor (HGF), monocyte chemoattractant protein-1 (MCP-1), and osteopontin, alongside reduced VEGF-A levels (all <em>P</em> < 0.01). Axial length correlated positively with VEGF-C, HGF, MCP-1, and osteopontin but negatively with VEGF-A. Increased PCO severity was associated with higher VEGF-C, HGF, MCP-1, and osteopontin levels, while VEGF-A levels were inversely related.</div></div><div><h3>Conclusion</h3><div>These findings suggest that high myopia is linked to a distinct pro-inflammatory and pro-fibrotic cytokine environment, potentially exacerbating PCO. Identifying these cytokines as potential biomarkers may aid in early risk stratification and inform therapeutic strategies to prevent PCO in individuals with high myopia.</div></div>","PeriodicalId":297,"journal":{"name":"Cytokine","volume":"194 ","pages":"Article 156995"},"PeriodicalIF":3.7000,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Cytokine","FirstCategoryId":"3","ListUrlMain":"https://www.sciencedirect.com/science/article/pii/S1043466625001425","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"BIOCHEMISTRY & MOLECULAR BIOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Background

Posterior capsular opacification (PCO) remains a significant complication following cataract surgery, with an unclear pathogenesis in patients with high myopia. This study investigated the aqueous humor (AH) cytokine profile in patients with cataracts and high myopia and its relationship with the development of PCO.

Methods

AH samples were collected from 36 patients undergoing cataract surgery, including 18 with high myopia (axial length > 26 mm) and 18 age- and sex-matched controls. The levels of 19 PCO-associated cytokines were measured using a multiplex immunoassay, and PCO severity was assessed at 6 months postoperatively.

Results

Compared to controls, patients with high myopia exhibited significantly elevated levels of vascular endothelial growth factor (VEGF)-C, hepatocyte growth factor (HGF), monocyte chemoattractant protein-1 (MCP-1), and osteopontin, alongside reduced VEGF-A levels (all P < 0.01). Axial length correlated positively with VEGF-C, HGF, MCP-1, and osteopontin but negatively with VEGF-A. Increased PCO severity was associated with higher VEGF-C, HGF, MCP-1, and osteopontin levels, while VEGF-A levels were inversely related.

Conclusion

These findings suggest that high myopia is linked to a distinct pro-inflammatory and pro-fibrotic cytokine environment, potentially exacerbating PCO. Identifying these cytokines as potential biomarkers may aid in early risk stratification and inform therapeutic strategies to prevent PCO in individuals with high myopia.

Abstract Image

查看原文本刊更多论文

房水细胞因子与高度近视患者后囊膜混浊的关系

背景：高度近视患者白内障术后后囊膜混浊（PCO）仍然是一个重要的并发症，其发病机制尚不清楚。本研究探讨了白内障和高度近视患者房水细胞因子的变化及其与后发性白内障的关系。方法收集36例白内障手术患者的sah样本，其中高度近视18例(眼轴长>；26毫米)和18个年龄和性别匹配的对照组。使用多重免疫分析法测量19种PCO相关细胞因子的水平，并在术后6个月评估PCO的严重程度。结果与对照组相比，高度近视患者的血管内皮生长因子(VEGF)-C、肝细胞生长因子（HGF）、单核细胞趋化蛋白-1 （MCP-1）和骨桥蛋白水平显著升高，VEGF- a水平降低(P <；0.01)。轴长与VEGF-C、HGF、MCP-1和骨桥蛋白呈正相关，与VEGF-A呈负相关。加重的PCO严重程度与较高的VEGF-C、HGF、MCP-1和骨桥蛋白水平相关，而VEGF-A水平呈负相关。结论高度近视与不同的促炎和促纤维化细胞因子环境有关，可能加剧PCO。识别这些细胞因子作为潜在的生物标志物可能有助于早期风险分层，并为高度近视患者预防PCO的治疗策略提供信息。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Cytokine 医学-免疫学

CiteScore

7.60

自引率

2.60%

发文量

262

审稿时长

48 days

期刊介绍： The journal Cytokine has an open access mirror journal Cytokine: X, sharing the same aims and scope, editorial team, submission system and rigorous peer review. * Devoted exclusively to the study of the molecular biology, genetics, biochemistry, immunology, genome-wide association studies, pathobiology, diagnostic and clinical applications of all known interleukins, hematopoietic factors, growth factors, cytotoxins, interferons, new cytokines, and chemokines, Cytokine provides comprehensive coverage of cytokines and their mechanisms of actions, 12 times a year by publishing original high quality refereed scientific papers from prominent investigators in both the academic and industrial sectors. We will publish 3 major types of manuscripts: 1) Original manuscripts describing research results. 2) Basic and clinical reviews describing cytokine actions and regulation. 3) Short commentaries/perspectives on recently published aspects of cytokines, pathogenesis and clinical results.