New insights into methionine’s role in maintaining intestinal stem cell regeneration via autophagy regulation

IF 6.1 1区农林科学 Q1 AGRICULTURE, DAIRY & ANIMAL SCIENCE

Animal Nutrition Pub Date : 2025-07-12 DOI:10.1016/j.aninu.2025.04.008

Yaxue Lv, Yuqing Feng, Jiandong Lu, Sheng Zhang, Yihan Wei, Chunqi Gao

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Abstract

As an essential amino acid, methionine (Met) is crucial for several biological functions, including protein synthesis, cell proliferation, and protection against oxidative stress. As research uncovers the role of Met in addressing conditions like colorectal cancer and colitis, understanding its mechanisms in promoting gut health becomes increasingly vital. This review highlights the importance of intestinal stem cells (ISCs) in maintaining gut stability and discusses the impact of autophagy on these stem cells. Additionally, it provides a comprehensive examination of Met's biological characteristics, metabolic pathways, and its regulatory effects on autophagy. Met has promising potential for innovation in both nutritional and therapeutic contexts through its regulation of autophagy. By emphasizing its role in enhancing gut health and its therapeutic capabilities for related diseases, this article offers fresh perspectives for developing food products and pharmaceuticals, paving the way for more in-depth research and applications in this area.

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蛋氨酸通过自噬调节在维持肠道干细胞再生中的作用的新见解

作为一种必需氨基酸，蛋氨酸（Met）在蛋白质合成、细胞增殖和抗氧化应激等生物学功能中起着至关重要的作用。随着研究揭示Met在解决结肠直肠癌和结肠炎等疾病中的作用，了解其促进肠道健康的机制变得越来越重要。这篇综述强调了肠干细胞（ISCs）在维持肠道稳定中的重要性，并讨论了自噬对这些干细胞的影响。此外，它还提供了Met的生物学特性，代谢途径及其对自噬的调节作用的全面检查。通过调节自噬，Met在营养和治疗方面都有很大的创新潜力。通过强调其在促进肠道健康和治疗相关疾病方面的作用，为食品和药物的开发提供了新的视角，为该领域更深入的研究和应用铺平了道路。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Animal Nutrition Agricultural and Biological Sciences-Animal Science and Zoology

CiteScore

7.40

自引率

3.20%

发文量

172

审稿时长

12 weeks

期刊介绍： Animal Nutrition encompasses the full gamut of animal nutritional sciences and reviews including, but not limited to, fundamental aspects of animal nutrition such as nutritional requirements, metabolic studies, body composition, energetics, immunology, neuroscience, microbiology, genetics and molecular and cell biology related to nutrition, and more applied aspects of animal nutrition, such as raw material evaluation, feed additives, nutritive value of novel ingredients and feed safety.