Revealing the order of chromatin reorganization events with Dam&ChIC

IF 19.1 1区生物学 Q1 CELL BIOLOGY

Nature Cell Biology Pub Date : 2025-07-14 DOI:10.1038/s41556-025-01710-0

引用次数: 0

Abstract

Epigenetic states are formed by the coordinated activity of several chromatin factors. Dam&ChIC recovers both past and current epigenetic states in single cells, revealing the timing and order of chromatin reorganization. It enabled us to identify how spatial chromatin localization is inherited upon mitosis, and to dissect successive chromatin remodeling events during the initiation of X-chromosome inactivation.

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用Dam&ChIC揭示染色质重组事件的顺序

表观遗传状态是由几个染色质因子的协调活动形成的。Dam&；ChIC在单个细胞中恢复过去和现在的表观遗传状态，揭示染色质重组的时间和顺序。它使我们能够确定空间染色质定位是如何在有丝分裂时遗传的，并在x染色体失活的起始阶段解剖连续的染色质重塑事件。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Nature Cell Biology 生物-细胞生物学

CiteScore

28.40

自引率

0.90%

发文量

219

审稿时长

3 months

期刊介绍： Nature Cell Biology, a prestigious journal, upholds a commitment to publishing papers of the highest quality across all areas of cell biology, with a particular focus on elucidating mechanisms underlying fundamental cell biological processes. The journal's broad scope encompasses various areas of interest, including but not limited to: -Autophagy -Cancer biology -Cell adhesion and migration -Cell cycle and growth -Cell death -Chromatin and epigenetics -Cytoskeletal dynamics -Developmental biology -DNA replication and repair -Mechanisms of human disease -Mechanobiology -Membrane traffic and dynamics -Metabolism -Nuclear organization and dynamics -Organelle biology -Proteolysis and quality control -RNA biology -Signal transduction -Stem cell biology