Patterns of medicinal cannabis prescriptions in diverse patient populations: a retrospective analysis.

IF 4.3 Q1 PHARMACOLOGY & PHARMACY
Omer Edni, Eviatar Naamany, Shimon Izhakian, Shachaf Shiber
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Abstract

Introduction: The use of medicinal cannabis is increasing worldwide and has applications in managing a wide range of conditions, including neurological, rheumatological, and gastrointestinal diseases. Despite its growing prevalence, there are limited data on patterns of cannabis prescription across varying disease groups and demographic subgroups.

Methods: This retrospective observational cohort study analysed cannabis usage patterns among 263 patients from the cannabis user clinic at Rabin Medical center (RMC), a tertiary hospital in Israel. To minimise the inclusion of recreational cannabis users, only patients aged 30 years and older were included. Patients were categorised into three groups based on their primary medical condition: neurological (n = 63), rheumatological (n = 106), and gastrointestinal (n = 94). Data collected included: demographic information, cannabis dosage, Tetrahydrocannabinol (THC) content, cultivated variety preference (sativa vs. Indica), and method of consumption (smoking vs. oil). Statistical analyses were conducted using ANOVA, Kruskal-Wallis, chi-square, and t-tests to compare cannabis prescription patterns between disease and demographic groups.

Results: Significant differences in cannabis prescription patterns were observed across disease groups. Patients with gastrointestinal conditions were prescribed the highest mean monthly cannabis dose (22.26 ± 13.60 g), while those with neurological conditions had the highest oil consumption (31.75%). Sex-based differences were notable, with male patients being prescribed significantly higher doses of cannabis (25.48 ± 15.15 g) and higher THC content (14 ± 6.56%) compared to female patients (17.32 ± 9.93 g; THC: 11.39 ± 6.48%).

Discussion: The study highlights variations in cannabis prescription patterns based on both medical conditions and demographic factors. Male patients received higher doses and THC-rich formulations, while patients with gastrointestinal conditions had the highest cannabis prescription overall. These findings suggest the need for individualised cannabis therapy based on patient characteristics and the specific condition being treated.

Conclusion: Medicinal cannabis usage patterns vary significantly across disease and demographic groups. Personalised cannabis treatment plans, informed by both clinical and demographic factors, are essential to optimising patient outcomes. Further research is needed to develop more precise guidelines for prescribing medicinal cannabis.

不同患者群体中药用大麻处方的模式:回顾性分析。
导论:药用大麻的使用在世界范围内正在增加,并在管理广泛的疾病中得到应用,包括神经、风湿病和胃肠道疾病。尽管大麻日益流行,但关于不同疾病群体和人口亚群体的大麻处方模式的数据有限。方法:这项回顾性观察队列研究分析了以色列Rabin医学中心(RMC)三级医院大麻使用者诊所263名患者的大麻使用模式。为了尽量减少娱乐性大麻使用者,只包括30岁及以上的患者。患者根据其主要医疗状况分为三组:神经系统(n = 63)、风湿病(n = 106)和胃肠道(n = 94)。收集的数据包括:人口统计信息、大麻剂量、四氢大麻酚(THC)含量、栽培品种偏好(sativa vs. Indica)和消费方式(吸烟vs.油)。采用方差分析、Kruskal-Wallis检验、卡方检验和t检验进行统计分析,比较疾病和人口群体之间的大麻处方模式。结果:在不同疾病组中观察到大麻处方模式的显着差异。胃肠道疾病患者的平均月大麻剂量最高(22.26±13.60 g),而神经系统疾病患者的油消耗量最高(31.75%)。性别差异显著,男性患者的大麻剂量(25.48±15.15 g)和THC含量(14±6.56%)明显高于女性患者(17.32±9.93 g);Thc: 11.39±6.48%)。讨论:该研究强调了基于医疗条件和人口因素的大麻处方模式的差异。男性患者接受更高剂量和富含四氢大麻酚的配方,而胃肠道疾病患者的大麻处方总体上最高。这些发现表明,需要根据患者的特点和治疗的具体情况进行个性化的大麻治疗。结论:药用大麻的使用模式在不同疾病和人口群体之间存在显著差异。根据临床和人口因素制定的个性化大麻治疗计划对于优化患者结果至关重要。需要进一步研究以制定更精确的药用大麻处方指南。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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CiteScore
6.20
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