How macrophages use extracellular calreticulin to chase their prey.

IF 6.5 2区医学 Q1 IMMUNOLOGY

Oncoimmunology Pub Date : 2025-12-01 Epub Date: 2025-07-12 DOI:10.1080/2162402X.2025.2533494

Liwei Zhao, Peng Liu, Oliver Kepp, Guido Kroemer

引用次数: 0

Abstract

Recent findings reveal that macrophages actively control clearance by desialylating target cells via NEU1 and releasing cathepsin-cleaved calreticulin (CALR) to mark them for phagocytosis. This uncovers a dual role for CALR as immune activator or repressor, depending on its form and context, with distinct implications for cancer immunity.

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巨噬细胞如何利用细胞外钙钙蛋白来追捕猎物。

最近的研究结果表明，巨噬细胞通过NEU1使靶细胞脱盐，并释放组织蛋白酶裂解钙网蛋白（CALR）来标记它们被吞噬，从而主动控制清除。这揭示了CALR作为免疫激活剂或抑制剂的双重作用，这取决于它的形式和环境，对癌症免疫有不同的影响。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Oncoimmunology ONCOLOGYIMMUNOLOGY-IMMUNOLOGY

CiteScore

12.50

自引率

2.80%

发文量

276

审稿时长

24 weeks

期刊介绍： OncoImmunology is a dynamic, high-profile, open access journal that comprehensively covers tumor immunology and immunotherapy. As cancer immunotherapy advances, OncoImmunology is committed to publishing top-tier research encompassing all facets of basic and applied tumor immunology. The journal covers a wide range of topics, including: -Basic and translational studies in immunology of both solid and hematological malignancies -Inflammation, innate and acquired immune responses against cancer -Mechanisms of cancer immunoediting and immune evasion -Modern immunotherapies, including immunomodulators, immune checkpoint inhibitors, T-cell, NK-cell, and macrophage engagers, and CAR T cells -Immunological effects of conventional anticancer therapies.