Stem Cell for Cancer Immunotherapy: Current Approaches and Challenges.

IF 4.2 3区医学 Q2 CELL & TISSUE ENGINEERING

Stem Cell Reviews and Reports Pub Date : 2025-07-12 DOI:10.1007/s12015-025-10933-5

Zainab Alali, Umme Tamanna Ferdous, Alexis Nzila, Farhana Easmin, Adnan Shakoor, Abdul Wasy Zia, Shihab Uddin

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Abstract

Stem cell-based immunotherapy represents a groundbreaking advancement in cancer treatment, leveraging the immune system's inherent capacity to target and eradicate cancer cells. This review explores some of the examples of stem cells used in cancer immunotherapy, including hematopoietic, mesenchymal, and induced pluripotent stem cells (IPSCs). It also describes stem cell functionalities like modifying tumor microenvironment (TME) and developing engineered immune cells like chimeric antigen receptor (CAR)-T cells and natural killer (NK) cells. Additionally, the clinical applications of stem cells for improving cancer immunotherapies and delivering drugs directly to solid tumors are discussed. However, several challenges limit the effectiveness of stem cell technology, including safety risks, tumor avoidance by the immune system, and regulatory protocols as well as manufacturing barriers. This article reviews current advancements to overcome these challenges, such as CRISPR-based gene editing and targeted drug delivery systems and provides an outlook on emerging trends, such as the progress of personalized stem cell therapies and the increasing effectiveness of treatment by combining them with other cancer treatments.

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干细胞用于癌症免疫治疗：目前的方法和挑战。

基于干细胞的免疫疗法代表了癌症治疗的突破性进展，利用免疫系统的固有能力来靶向和根除癌细胞。这篇综述探讨了一些干细胞用于癌症免疫治疗的例子，包括造血干细胞、间充质干细胞和诱导多能干细胞（IPSCs）。它还描述了干细胞的功能，如修饰肿瘤微环境（TME）和开发工程免疫细胞，如嵌合抗原受体(CAR)-T细胞和自然杀伤（NK）细胞。此外，还讨论了干细胞在改善癌症免疫治疗和直接向实体肿瘤输送药物方面的临床应用。然而，一些挑战限制了干细胞技术的有效性，包括安全风险、免疫系统的肿瘤规避、监管协议以及制造障碍。本文回顾了当前克服这些挑战的进展，例如基于crispr的基因编辑和靶向药物递送系统，并展望了新兴趋势，例如个性化干细胞治疗的进展以及通过将其与其他癌症治疗相结合来提高治疗效果。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Stem Cell Reviews and Reports 医学-细胞生物学

CiteScore

9.30

自引率

4.20%

发文量

审稿时长

3 months

期刊介绍： The purpose of Stem Cell Reviews and Reports is to cover contemporary and emerging areas in stem cell research and regenerative medicine. The journal will consider for publication: i) solicited or unsolicited reviews of topical areas of stem cell biology that highlight, critique and synthesize recent important findings in the field. ii) full length and short reports presenting original experimental work. iii) translational stem cell studies describing results of clinical trials using stem cells as therapeutics. iv) papers focused on diseases of stem cells. v) hypothesis and commentary articles as opinion-based pieces in which authors can propose a new theory, interpretation of a controversial area in stem cell biology, or a stem cell biology question or paradigm. These articles contain more speculation than reviews, but they should be based on solid rationale. vi) protocols as peer-reviewed procedures that provide step-by-step descriptions, outlined in sufficient detail, so that both experts and novices can apply them to their own research. vii) letters to the editor and correspondence. In order to facilitate this exchange of scientific information and exciting novel ideas, the journal has created five thematic sections, focusing on: i) the role of adult stem cells in tissue regeneration; ii) progress in research on induced pluripotent stem cells, embryonic stem cells and mechanism governing embryogenesis and tissue development; iii) the role of microenvironment and extracellular microvesicles in directing the fate of stem cells; iv) mechanisms of stem cell trafficking, stem cell mobilization and homing with special emphasis on hematopoiesis; v) the role of stem cells in aging processes and cancerogenesis.