Development and Characterization of Self-Adhesive Polymeric Films with Antiallergic Effect.

IF 4.7 3区工程技术 Q1 POLYMER SCIENCE

Polymers Pub Date : 2025-07-03 DOI:10.3390/polym17131867

Ioana Savencu, Sonia Iurian, Cătălina Bogdan, Valentin Toma, Rareș Știufiuc, Ioan Tomuță

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Abstract

This study aimed to design self-adhesive cutaneous films with an antiallergic effect using a Design of Experiments approach. The active pharmaceutical ingredient (API) was diphenhydramine hydrochloride (DPH). A full factorial experimental design with three factors and two levels was created. The factors were the polyvinyl alcohol (PVA) ratio, the polyacrylic acid (PAA) ratio, and the type of plasticizer. The responses evaluated were hardness, deformation at hardness, adhesive force, and in vitro DPH release profile. Eleven formulations were generated, prepared in two steps via solvent casting, and characterized in terms of mechanical and adhesive properties, as well as the in vitro DPH release profile. The PVA ratio had the most significant impact on the responses, followed by PEG 400 and PEG 4000. Four film formulations were investigated using Raman spectroscopy, which revealed that the API was distributed in both the base and adhesive layers. Consequently, an optimal formulation was prepared and characterized. Good mechanical properties (a hardness of 463.7 g and a deformation at hardness of 16.56 mm) and an increased adhesive force (76 g) were observed, while the DPH was released up to 68% over 12 h. In conclusion, a novel self-adhesive film was developed, which may enhance patients' adherence to local antiallergic treatment.

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抗过敏自粘高分子薄膜的研制与表征。

本研究旨在采用实验设计方法设计具有抗过敏作用的自粘皮肤薄膜。活性药物成分为盐酸苯海拉明（DPH）。采用三因素两水平全因子试验设计。影响因素有聚乙烯醇（PVA）比、聚丙烯酸（PAA）比和增塑剂种类。评价其硬度、硬度变形、附着力和体外DPH释放曲线。通过溶剂铸造两步制备了11种配方，并对其机械性能和粘接性能以及体外DPH释放特性进行了表征。PVA比对反应的影响最显著，其次是peg400和peg4000。利用拉曼光谱对四种薄膜配方进行了研究，结果表明原料药分布在基材层和粘结层中。从而制备了最佳配方并对其进行了表征。实验结果表明，DPH具有良好的力学性能（硬度为463.7 g，变形硬度为16.56 mm），粘结力（76 g）增加，12 h内释放率高达68%。由此可见，制备出一种新型自粘膜，可增强患者对局部抗过敏治疗的依从性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Polymers POLYMER SCIENCE-

CiteScore

8.00

自引率

16.00%

发文量

4697

审稿时长

1.3 months

期刊介绍： Polymers (ISSN 2073-4360) is an international, open access journal of polymer science. It publishes research papers, short communications and review papers. Our aim is to encourage scientists to publish their experimental and theoretical results in as much detail as possible. Therefore, there is no restriction on the length of the papers. The full experimental details must be provided so that the results can be reproduced. Polymers provides an interdisciplinary forum for publishing papers which advance the fields of (i) polymerization methods, (ii) theory, simulation, and modeling, (iii) understanding of new physical phenomena, (iv) advances in characterization techniques, and (v) harnessing of self-assembly and biological strategies for producing complex multifunctional structures.