Mupirocin: A Useful Antibiotic for Methicillin-Resistant Staphylococcus aureus Decolonization: A Narrative Review.

IF 1.9 4区医学 Q3 INFECTIOUS DISEASES

Microbial drug resistance Pub Date : 2025-08-01 Epub Date: 2025-07-11 DOI:10.1177/10766294251358764

Yasin Saberi, Kasra Javadi, Arezoo Mirzaei, Mehrdad Halaji

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引用次数: 0

Abstract

Mupirocin (MUP) is a topical antibiotic derived from Pseudomonas fluorescens, widely used for the treatment of superficial skin infections and decolonization of methicillin-resistant Staphylococcus aureus (MRSA). Its unique mechanism of action, selective inhibition of bacterial isoleucyl-transfer RNA synthetase, confers high specificity with minimal risk of cross-resistance to other antibiotic classes. This narrative review provides an updated overview of MUP's chemical structure, mechanism of action, clinical efficacy, resistance mechanisms, and global resistance trends based on literature published from 2017 to 2024. Recent clinical studies confirm MUP's continued effectiveness, particularly in the decolonization of MRSA nasal infections. However, resistance, including high-level MUP resistance mediated by the mupA and mupB genes, is increasingly reported worldwide. A better understanding of resistance patterns and judicious use of MUP is essential to preserving its clinical utility in the context of rising antimicrobial resistance.

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莫匹罗星：耐甲氧西林金黄色葡萄球菌非定殖的有效抗生素：叙述性回顾。

莫匹罗星（MUP）是一种从荧光假单胞菌中提取的外用抗生素，广泛用于治疗浅表皮肤感染和耐甲氧西林金黄色葡萄球菌（MRSA）的去菌落。其独特的作用机制，选择性抑制细菌异亮基转移RNA合成酶，具有高特异性，对其他抗生素类交叉耐药的风险最小。本文基于2017年至2024年发表的文献，对MUP的化学结构、作用机制、临床疗效、耐药机制和全球耐药趋势进行了综述。最近的临床研究证实了MUP的持续有效性，特别是在MRSA鼻腔感染的去菌落方面。然而，抗性，包括由mupA和mupB基因介导的高水平MUP抗性，在世界范围内越来越多地报道。更好地了解耐药模式和明智地使用MUP对于在抗菌素耐药性上升的背景下保持其临床效用至关重要。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Microbial drug resistance 医学-传染病学

CiteScore

6.00

自引率

3.80%

发文量

118

审稿时长

6-12 weeks

期刊介绍： Microbial Drug Resistance (MDR) is an international, peer-reviewed journal that covers the global spread and threat of multi-drug resistant clones of major pathogens that are widely documented in hospitals and the scientific community. The Journal addresses the serious challenges of trying to decipher the molecular mechanisms of drug resistance. MDR provides a multidisciplinary forum for peer-reviewed original publications as well as topical reviews and special reports. MDR coverage includes: Molecular biology of resistance mechanisms Virulence genes and disease Molecular epidemiology Drug design Infection control.