LINC01410 in cancer: a comprehensive review of its oncogenic role, regulatory mechanisms, and clinical implications.

Abstract

LINC01410 is classified as a long non-coding RNA (lncRNA) that plays a pivotal role in cancer biology. Non-coding RNAs, including lncRNAs, have been recognized for their significant regulatory functions in various cellular processes, making them crucial for understanding the mechanisms underlying cancer development and progression. This review aims to synthesize the current knowledge of LINC01410's contributions to cancer development, and progression across different tumor types, highlighting its potential roles as a biomarker and therapeutic target. A comprehensive literature review was performed, encompassing experimental, clinical, and bioinformatics studies that examined LINC01410's expression profiles and functional roles in various cancers. Studies were selected based on their relevance to LINC01410's involvement in oncogenic processes and their methodological rigor. LINC01410 exhibits differential expression in several cancers, often correlates with tumor aggressiveness and patient prognosis. Mechanistically, LINC01410 acts as a competing endogenous RNA, regulating gene expression by sequestering microRNAs, which in turn modulates the expression of target mRNAs. This lncRNA has been implicated in promoting cancer cell proliferation, invasion, lymphangiogenesis, and chemoradiotherapy resistance underscoring its multifaceted roles in tumor biology. The exploration of LINC01410 has important implications in cancer diagnosis and therapy, positioning it as a potential biomarker for disease progression and a therapeutic target for intervention strategies.