Provision of additional oral nutritional supplements to postgastrectomy patients based on regular diet intake to meet their energy requirements reduces body weight loss.

IF 2.6 Q3 NUTRITION & DIETETICS

Clinical nutrition ESPEN Pub Date : 2025-07-10 DOI:10.1016/j.clnesp.2025.07.015

Hitoshi Harada, Shingo Kanaji, Moe Tsuboi, Saki Nakatani, Satoko Tabuchi, Ikuko Yamamoto, Yutaka Sugita, Taro Ikeda, Yasufumi Koterazawa, Tomoaki Aoki, Yasunori Otowa, Naoki Urakawa, Hironobu Goto, Hiroshi Hasegawa, Kimihiro Yamashita, Takeru Matsuda, Michiko Takahashi, Yoshihiro Kakeji

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引用次数: 0

Abstract

Background & aims: Oral nutritional supplements (ONS) administered after gastrectomies can prevent postoperative weight loss. However, the amount of additional energy to be added to energy requirements after gastrectomy is unclear. This study aimed to clarify dietary energy intake and its association with weight loss in postgastrectomy patients.

Methods: We performed a single-center, single-arm, open-label, non-randomized clinical trial. Fifty patients with gastric cancer who underwent distal or total gastrectomy were included in this study. Until 3 months postoperatively, the patients continuously consumed ONS and their intake was recorded. Additionally, the patients took photos of their regular diets. Hospital visits were made every 2 weeks to investigate calorie intake (from regular diet plus ONS), physical findings, and nutritional status. The primary endpoint was the percentage of body weight loss (%BWL) at 3 months after gastrectomy.

Results: Data were available for 45 patients. %BWL was 7.5±5.1% at 3 months postoperatively. The group with ONS intake <200 kcal/day tended to show a lower %BWL; however, this was not significant. No correlation was observed between ONS and regular dietary calorie intake. The required calorie intake was 1588±157 kcal/day. Calorie intake from regular diet alone and from regular diet plus ONS were 1330±280 and 1487±300 kcal/day, respectively. The sufficient group, whose total calorie intake met the requirements, had significantly reduced body weight loss, compared with the insufficient group.

Conclusions: After gastrectomy, regular diet alone often fails to meet nutritional requirements, and ONS supplementation may reduce %BWL at 3 months postoperatively by correcting energy deficits. This study was registered with the University Hospital Medical Information Network Clinical Trial Registry (UMIN-CTR; UMIN000047451; https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000054111).

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在正常饮食摄入的基础上，为胃切除术后患者提供额外的口服营养补充剂，以满足其能量需求，可减少体重减轻。

背景与目的：胃切除术后口服营养补充剂（ONS）可以预防术后体重减轻。然而，胃切除术后需要补充多少能量还不清楚。本研究旨在阐明胃切除术后患者的膳食能量摄入及其与体重减轻的关系。方法：我们进行了一项单中心、单臂、开放标签、非随机临床试验。本研究纳入了50例接受远端或全胃切除术的胃癌患者。直到术后3个月，患者持续食用ONS并记录其摄入量。此外，患者还拍摄了他们日常饮食的照片。每两周进行一次医院访问，以调查卡路里摄入量（来自常规饮食和ONS）、身体检查结果和营养状况。主要终点是胃切除术后3个月体重减轻的百分比（%BWL）。结果：获得45例患者的资料。术后3个月BWL为7.5±5.1%。结论：胃切除术后，单靠常规饮食往往不能满足营养需求，补充ONS可通过纠正能量不足，在术后3个月降低%的体重。本研究已在大学医院医学信息网络临床试验注册中心(UMIN-CTR；UMIN000047451;https://center6.umin.ac.jp/cgi-open-bin/ctr/ctr_view.cgi?recptno=R000054111)。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Clinical nutrition ESPEN NUTRITION & DIETETICS-

CiteScore

4.90

自引率

3.30%

发文量

512

期刊介绍： Clinical Nutrition ESPEN is an electronic-only journal and is an official publication of the European Society for Clinical Nutrition and Metabolism (ESPEN). Nutrition and nutritional care have gained wide clinical and scientific interest during the past decades. The increasing knowledge of metabolic disturbances and nutritional assessment in chronic and acute diseases has stimulated rapid advances in design, development and clinical application of nutritional support. The aims of ESPEN are to encourage the rapid diffusion of knowledge and its application in the field of clinical nutrition and metabolism. Published bimonthly, Clinical Nutrition ESPEN focuses on publishing articles on the relationship between nutrition and disease in the setting of basic science and clinical practice. Clinical Nutrition ESPEN is available to all members of ESPEN and to all subscribers of Clinical Nutrition.