Association of homozygous fat mass and obesity-associated (FTO rs9939609) gene with body mass, body mass index (BMI), and the binge eating scale in women: A cross-sectional study

IF 2.6 Q3 NUTRITION & DIETETICS

Clinical nutrition ESPEN Pub Date : 2025-07-09 DOI:10.1016/j.clnesp.2025.07.016

Annete Bressan Rente Ferreira Marum , Aline Boveto Santamarina , Pedro Andrade , Ana Flávia Marçal Pessoa , Bruna Vidal Dias , Maria Arlete Meil Schimith Escrivão

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引用次数: 0

Abstract

Background & aims

This study aimed to investigate the association between the homozygous fat mass and obesity-associated (FTO rs9939609) risk genotype and body weight, body mass index (BMI), and binge eating behavior in a women cross-sectional study. Specifically, it sought to assess whether the FTO polymorphism correlates with increased BMI and scores on the Binge Eating Scale (BES).

Methods

A cross-sectional study was conducted with 80 women who provided data on body weight, BMI, and BES scores. Genotypic analysis for the FTO rs9939609 gene was performed, grouping participants into three genotypes: TT (wild-type), AT (heterozygous), and AA (homozygous risk). Anthropometric measures were collected either in person or through self-reported methods. Statistical analyses included Kruskal–Wallis tests, Fisher's exact test, and logistic regression to assess associations between genotype and study outcomes.

Results

The AA homozygous genotype was significantly associated with higher body weight and BMI compared to the TT and AT groups (p = 0.004 and p = 0.008, respectively). Moreover, AA carriers exhibited higher BES scores, indicating a greater predisposition to binge eating behavior (p = 0.043). Logistic regression revealed that the AA genotype had a higher odds ratio for elevated body weight, BMI, and BES scores compared to the TT genotype.

Conclusions

The FTO rs9939609 polymorphism, particularly the homozygous risk genotype (AA), is associated with increased body weight, BMI, and binge eating behavior in women. These findings highlight the genetic contribution to obesity and eating disorders, offering potential implications for personalized interventions targeting those at higher genetic risk.

Ethical approval

Universidade Federal de São Paulo Ethics Committee (CEP-UNIFESP No.0565/2018).

查看原文本刊更多论文

纯合子脂肪量和肥胖相关（FTO rs9939609）基因与女性体重、体重指数（BMI）和暴食规模的关联：一项横断面研究

背景与目的：本研究旨在探讨纯合子脂肪量与肥胖相关（FTO rs9939609）风险基因型与女性体重、体重指数（BMI）和暴饮暴食行为之间的关系。具体来说，它试图评估FTO多态性是否与增加的BMI和暴饮暴食量表（BES）得分相关。方法：对80名提供体重、BMI和BES评分数据的女性进行横断面研究。对FTO rs9939609基因进行基因型分析，将参与者分为三种基因型：TT（野生型）、AT（杂合型）和AA（纯合风险型）。人体测量数据的收集可以是亲自或通过自我报告的方法。统计分析包括Kruskal-Wallis检验、Fisher精确检验和逻辑回归来评估基因型与研究结果之间的关系。结果：与TT组和AT组相比，AA纯合子基因型与较高的体重和BMI显著相关（p = 0.004和p = 0.008）。此外，AA携带者的BES得分较高，表明其更容易出现暴食行为（p = 0.043）。Logistic回归分析显示，与TT基因型相比，AA基因型在体重、BMI和BES评分方面具有更高的优势比。结论：FTO rs9939609多态性，特别是纯合风险基因型（AA），与女性体重、BMI和暴饮暴食行为增加有关。这些发现强调了遗传因素对肥胖和饮食失调的影响，为针对遗传风险较高的人群进行个性化干预提供了潜在的启示。伦理审批：圣保罗联邦大学伦理委员会（CEP-UNIFESP No.0565/2018）。

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来源期刊

Clinical nutrition ESPEN NUTRITION & DIETETICS-

CiteScore

4.90

自引率

3.30%

发文量

512

期刊介绍： Clinical Nutrition ESPEN is an electronic-only journal and is an official publication of the European Society for Clinical Nutrition and Metabolism (ESPEN). Nutrition and nutritional care have gained wide clinical and scientific interest during the past decades. The increasing knowledge of metabolic disturbances and nutritional assessment in chronic and acute diseases has stimulated rapid advances in design, development and clinical application of nutritional support. The aims of ESPEN are to encourage the rapid diffusion of knowledge and its application in the field of clinical nutrition and metabolism. Published bimonthly, Clinical Nutrition ESPEN focuses on publishing articles on the relationship between nutrition and disease in the setting of basic science and clinical practice. Clinical Nutrition ESPEN is available to all members of ESPEN and to all subscribers of Clinical Nutrition.