Kidney failure and oral health - A systematic review and meta-analysis of observational studies.

IF 0.9 4区医学 Q3 DENTISTRY, ORAL SURGERY & MEDICINE

Community dental health Pub Date : 2025-07-12 DOI:10.1177/0265539X251355212

Galileu Bottermund Galli, Eduardo Ribes Kohn, Pedro Bohlke Barcellos, Luísa Casarin Rickes, Maristela Bohlke

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引用次数: 0

Abstract

Background: The interplay between oral health and chronic kidney disease (CKD) is not fully understood, but both conditions may influence each other through chronic inflammatory states. This systematic review and meta-analysis aim to investigate the association between CKD and oral health.

Methods: The review included observational studies (cross-sectional, case-control, and cohort) involving adults (≥18 years) comparing individuals with and without CKD regarding the number of missing teeth, edentulism, or the decayed, missing, and filled teeth (DMFT) index, a recognized indicator of oral health. The databases PubMed, Scopus, and Web of Science, together with references, were searched up to October 10, 2024. The results were synthesized using meta-analysis in RevMan software.

Results: Eight case-control studies from Portugal, Turkey, Japan, Brazil, and Thailand were included, with sample sizes ranging from 30 to 204 participants. CKD patients had significantly more missing teeth (mean difference +3.17; 95% CI 2.07-4.28), fewer filled teeth (mean difference -1.23; 95% CI -1.82; -0.64), and higher DMFT scores (mean difference +2.60; 95% CI 1.34; 3.86) compared to controls. No significant difference was found in the number of decayed teeth (mean difference 0.31; 95% CI -0.15; 0.76). The methodological quality of studies ranged from 4 to 7 stars.

Conclusions: Patients with CKD, especially those on hemodialysis, experience more tooth loss and higher DMFT scores, highlighting a gap in oral health care within dialysis units. Although the findings highlight the importance of addressing oral health in CKD patients, further studies are needed in developed countries to better understand the interplay between both conditions.

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肾衰竭和口腔健康——观察性研究的系统回顾和荟萃分析。

背景：口腔健康与慢性肾脏疾病（CKD）之间的相互作用尚不完全清楚，但两者可能通过慢性炎症状态相互影响。本系统综述和荟萃分析旨在调查CKD与口腔健康之间的关系。方法：本综述纳入观察性研究（横断面、病例对照和队列），涉及成人（≥18岁），比较有和没有CKD的个体在缺牙、全牙症或蛀牙、缺牙和补牙（DMFT）指数方面的数量，DMFT指数是公认的口腔健康指标。截止到2024年10月10日，PubMed、Scopus和Web of Science数据库以及参考文献均被检索到。在RevMan软件中对结果进行meta分析。结果：包括来自葡萄牙、土耳其、日本、巴西和泰国的8项病例对照研究，样本量从30人到204人不等。CKD患者缺牙明显多于CKD患者(平均差+3.17；95% CI 2.07-4.28)，补牙较少(平均差-1.23；95% ci -1.82；-0.64)， DMFT评分较高(平均差值+2.60；95% ci 1.34；3.86)。两组龋齿数差异无统计学意义(平均差0.31；95% ci -0.15；0.76)。研究的方法学质量从4星到7星不等。结论：CKD患者，特别是那些接受血液透析的患者，经历更多的牙齿脱落和更高的DMFT评分，突出了透析单位内口腔卫生保健的差距。尽管研究结果强调了解决CKD患者口腔健康问题的重要性，但发达国家需要进一步的研究来更好地了解这两种疾病之间的相互作用。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Community dental health 医学-牙科与口腔外科

CiteScore

2.20

自引率

11.80%

发文量

审稿时长

6-12 weeks

期刊介绍： The journal is concerned with dental public health and related subjects. Dental public health is the science and the art of preventing oral disease, promoting oral health, and improving the quality of life through the organised efforts of society. The discipline covers a wide range and includes such topics as: -oral epidemiology- oral health services research- preventive dentistry - especially in relation to communities- oral health education and promotion- clinical research - with particular emphasis on the care of special groups- behavioural sciences related to dentistry- decision theory- quality of life- risk analysis- ethics and oral health economics- quality assessment. The journal publishes scientific articles on the relevant fields, review articles, discussion papers, news items, and editorials. It is of interest to dentists working in dental public health and to other professionals concerned with disease prevention, health service planning, and health promotion throughout the world. In the case of epidemiology of oral diseases the Journal prioritises national studies unless local studies have major methodological innovations or information of particular interest.