Structural rearrangements affect blastocyst development.

IF 2.1 3区医学 Q2 OBSTETRICS & GYNECOLOGY

Archives of Gynecology and Obstetrics Pub Date : 2025-07-12 DOI:10.1007/s00404-025-08101-8

Yizi Wang, Yuanlin Ma, Yanling Tan, Jing Wang, Jiafu Pan, Junli Song, Yali Wang, Yanwen Xu

{"title":"Structural rearrangements affect blastocyst development.","authors":"Yizi Wang, Yuanlin Ma, Yanling Tan, Jing Wang, Jiafu Pan, Junli Song, Yali Wang, Yanwen Xu","doi":"10.1007/s00404-025-08101-8","DOIUrl":null,"url":null,"abstract":"Purpose: It is disputable whether chromosomal translocations lead to an inferior embryo development. The purpose of this study was to evaluate whether structural rearrangements (SR) affect blastocyst formation as compared to monogenic disorders in preimplantation genetic testing (PGT) cycles.Methods: A total of 791 PGT-SR cycles and 757 PGT-M cycles from January 2021 to May 2023 were included.Results: Lower blastocyst formation (graded 3BB or higher) rate was detected in the PGT-SR group compared with the control PGT-M group. In addition, lower proportion of day 5 blastocysts was found in the PGT-SR group compared with the control PGT-M group. Overall, a comparatively 12.7% lower proportion of eligible blastocysts in PGT-SR cycles. As expected, there were fewer balanced/normal blastocysts for transfer in the PGT-SR group (balanced/normal blastocysts rate, 32.3 vs. 59.9%, P = 0.02). The estimated curve by inverse model showed that yields of transferrable balanced/normal blastocyst per cycle came to a plateau stage followed with a rapid rise once the oocytes retrieved reached to the number of 20.4 in PGT-M cycle and 28.3 in PGT-SR cycle respectively.Conclusions: Our results demonstrated that patients with SR had a high chance of obtaining lower blastocyst development and significantly fewer usable blastocysts available for transfer compared to PGT-M in their first ovarian stimulation cycle.","PeriodicalId":8330,"journal":{"name":"Archives of Gynecology and Obstetrics","volume":" ","pages":""},"PeriodicalIF":2.1000,"publicationDate":"2025-07-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Archives of Gynecology and Obstetrics","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1007/s00404-025-08101-8","RegionNum":3,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"OBSTETRICS & GYNECOLOGY","Score":null,"Total":0}

引用次数: 0

Abstract

Purpose: It is disputable whether chromosomal translocations lead to an inferior embryo development. The purpose of this study was to evaluate whether structural rearrangements (SR) affect blastocyst formation as compared to monogenic disorders in preimplantation genetic testing (PGT) cycles.

Methods: A total of 791 PGT-SR cycles and 757 PGT-M cycles from January 2021 to May 2023 were included.

Results: Lower blastocyst formation (graded 3BB or higher) rate was detected in the PGT-SR group compared with the control PGT-M group. In addition, lower proportion of day 5 blastocysts was found in the PGT-SR group compared with the control PGT-M group. Overall, a comparatively 12.7% lower proportion of eligible blastocysts in PGT-SR cycles. As expected, there were fewer balanced/normal blastocysts for transfer in the PGT-SR group (balanced/normal blastocysts rate, 32.3 vs. 59.9%, P = 0.02). The estimated curve by inverse model showed that yields of transferrable balanced/normal blastocyst per cycle came to a plateau stage followed with a rapid rise once the oocytes retrieved reached to the number of 20.4 in PGT-M cycle and 28.3 in PGT-SR cycle respectively.

Conclusions: Our results demonstrated that patients with SR had a high chance of obtaining lower blastocyst development and significantly fewer usable blastocysts available for transfer compared to PGT-M in their first ovarian stimulation cycle.

查看原文本刊更多论文

结构重排影响囊胚发育。

目的：染色体易位是否导致胚胎发育不佳尚存争议。本研究的目的是评估在着床前基因检测（PGT）周期中，与单基因疾病相比，结构重排（SR）是否会影响囊胚形成。方法：纳入2021年1月至2023年5月共791个PGT-SR周期和757个PGT-M周期。结果：与对照PGT-M组相比，PGT-SR组囊胚形成率（分级为3BB或更高）较低。此外，与对照PGT-M组相比，PGT-SR组第5天囊胚比例较低。总体而言，PGT-SR周期中符合条件的囊胚比例相对低12.7%。正如预期的那样，PGT-SR组用于移植的平衡/正常囊胚较少（平衡/正常囊胚率，32.3 vs. 59.9%, P = 0.02）。逆模型估计曲线显示，每周期可转移平衡/正常囊胚的数量达到平台期，当回收的卵母细胞分别达到PGT-M周期的20.4个和PGT-SR周期的28.3个时，可转移囊胚数量迅速上升。结论：我们的研究结果表明，与PGT-M相比，SR患者在第一个卵巢刺激周期中获得较低囊胚发育的几率很高，可用于移植的囊胚明显减少。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

求助全文

约1分钟内获得全文求助全文

来源期刊

Archives of Gynecology and Obstetrics 医学-妇产科学

CiteScore

4.70

自引率

15.40%

发文量

493

审稿时长

1 months

期刊介绍： Founded in 1870 as "Archiv für Gynaekologie", Archives of Gynecology and Obstetrics has a long and outstanding tradition. Since 1922 the journal has been the Organ of the Deutsche Gesellschaft für Gynäkologie und Geburtshilfe. "The Archives of Gynecology and Obstetrics" is circulated in over 40 countries world wide and is indexed in "PubMed/Medline" and "Science Citation Index Expanded/Journal Citation Report". The journal publishes invited and submitted reviews; peer-reviewed original articles about clinical topics and basic research as well as news and views and guidelines and position statements from all sub-specialties in gynecology and obstetrics.