The Effects of External Cue Overlap and Internal Goals on Selective Memory Retrieval as Revealed by Electroencephalographic (EEG) Neural Pattern Reinstatement

IF 2.4 4区 医学 Q3 NEUROSCIENCES
Arianna Moccia, Matthew Plummer, Ivor Simpson, Alexa M. Morcom
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Abstract

For past experiences to guide our actions, we need to retrieve the relevant memories. Here, we used electroencephalography (EEG) to investigate how memories are selected for retrieval and to test how current goals and external retrieval cues drive selection during the retrieval cascade. We analysed data from two studies in which people studied objects in picture or auditory word formats and later recalled them using either written words (Experiment 1, n = 28) or line drawings (Experiment 2, n = 28) as retrieval cues. We used multivariate decoding to quantify the reinstatement of study phase neural patterns when people successfully identified items that had been studied in a format currently designated as targeted, compared with non-targeted items. Neural reinstatement emerged at around 500 ms post-stimulus, like the established left parietal event-related potential (ERP) signature of recollection. Reinstatement was target-selective (greater for targets than non-targets) when test cues overlapped more with targets, a pattern previously shown for the left parietal ERP. In contrast, when cues overlapped more with non-targets, neural reinstatement was reversed—greater for non-targets—unlike the left parietal ERP. We also tested for goal-directed mental reinstatement proposed to guide selection prior to retrieval cues. When words were cues, there was strong evidence of this proactive reinstatement, but it was not detected when pictures were cues. Together, the data suggest that selection can act at multiple stages of memory retrieval and depends on both external cues and goal-directed control.

Abstract Image

外部线索重叠和内部目标对选择性记忆提取的影响:脑电图神经模式恢复研究
为了让过去的经验指导我们的行动,我们需要找回相关的记忆。在这里,我们使用脑电图(EEG)来研究记忆是如何被选择用于检索的,并测试在检索级联过程中当前目标和外部检索线索是如何驱动选择的。我们分析了两项研究的数据,在这两项研究中,人们以图片或听觉形式学习物体,然后用书面文字(实验1,n = 28)或线条图(实验2,n = 28)作为检索线索来回忆它们。我们使用多元解码来量化研究阶段神经模式的恢复,当人们成功地识别出以当前指定为目标的格式研究过的项目时,与非目标项目相比。刺激后约500 ms出现神经恢复,如建立的左顶叶事件相关电位(ERP)特征的回忆。当测试线索与目标重叠更多时,恢复是目标选择性的(目标比非目标更强),这是先前在左顶叶ERP中显示的模式。相反,当线索与非目标重叠更多时,与左顶叶ERP不同的是,神经恢复是相反的——非目标的神经恢复更大。我们还测试了目标导向的心理恢复,建议在检索线索之前指导选择。当文字作为线索时,有强有力的证据表明这种主动恢复,但当图片作为线索时,没有发现这种情况。总之,这些数据表明,选择可以在记忆检索的多个阶段起作用,并且依赖于外部线索和目标导向控制。
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来源期刊
European Journal of Neuroscience
European Journal of Neuroscience 医学-神经科学
CiteScore
7.10
自引率
5.90%
发文量
305
审稿时长
3.5 months
期刊介绍: EJN is the journal of FENS and supports the international neuroscientific community by publishing original high quality research articles and reviews in all fields of neuroscience. In addition, to engage with issues that are of interest to the science community, we also publish Editorials, Meetings Reports and Neuro-Opinions on topics that are of current interest in the fields of neuroscience research and training in science. We have recently established a series of ‘Profiles of Women in Neuroscience’. Our goal is to provide a vehicle for publications that further the understanding of the structure and function of the nervous system in both health and disease and to provide a vehicle to engage the neuroscience community. As the official journal of FENS, profits from the journal are re-invested in the neuroscientific community through the activities of FENS.
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