White Matter Correlates of Psychopathic Traits in a Japanese Community Sample: Sex Matters!

IF 2.4 4区 医学 Q3 NEUROSCIENCES
S. C. Chester, J. C. Rogers, T. Ogawa, M. Terao, R. Nakai, N. Abe, S. A. De Brito
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Abstract

Psychopathy is a personality disorder marked by distinct interpersonal, affective and behavioural abnormalities. Relatively little is known about associations between psychopathic traits and white matter (WM) microstructure among community samples, as most diffusion tensor imaging (DTI) research has focused on small clinical and forensic samples. These studies are also often limited to males from Western populations, leaving gaps in the understanding of females and non-Western populations. This study uses DTI data from a large community sample (n = 97) of well-functioning Japanese adults (45 males, aged 21–39 years). We used tract-based spatial statistics to investigate WM microstructural integrity (whole brain corrected using threshold-free cluster enhancement (TFCE), p < 0.05). Psychopathy traits were measured using the Self-Report Psychopathy Scale (SRP-SF). Region of interest analysis showed that callous affect scores negatively correlated with fractional anisotropy and axial diffusivity in the left cingulum. Furthermore, analysis across the entire white matter skeleton revealed that sex acted as a moderator in the association between psychopathy trait scores and mean diffusivity (MD) in the right superior longitudinal fasciculus, anterior thalamic radiation, and corpus callosum. The interaction showed that psychopathy trait scores were positively associated with MD in females, whereas the opposite pattern was observed in males. Our findings offer novel insights into the white matter correlates of psychopathic traits.

Abstract Image

日本社区样本中的白质与精神病特征相关:性别问题!
精神病是一种人格障碍,其特征是明显的人际、情感和行为异常。由于大多数扩散张量成像(DTI)研究都集中在小型临床和法医样本上,因此对社区样本中精神病态特征与白质(WM)微观结构之间的关系知之甚少。这些研究也经常局限于来自西方人群的男性,在对女性和非西方人群的理解上留下了空白。本研究使用了一个大型社区样本(n = 97)的功能良好的日本成年人(45名男性,年龄21-39岁)的DTI数据。我们使用基于束的空间统计来研究WM微结构完整性(使用无阈值聚类增强(TFCE)校正全脑,p < 0.05)。使用自我报告精神病量表(SRP-SF)测量精神病特征。兴趣区分析显示,胼胝质影响评分与左扣带分数各向异性和轴向扩散率呈负相关。此外,对整个白质骨架的分析表明,性别在精神病特征得分和右上纵束、丘脑前辐射和胼胝体的平均扩散度(MD)之间的关联中起调节作用。相互作用表明,女性精神病特质得分与MD呈正相关,而男性则相反。我们的发现对白质与精神病特征的关系提供了新的见解。
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来源期刊
European Journal of Neuroscience
European Journal of Neuroscience 医学-神经科学
CiteScore
7.10
自引率
5.90%
发文量
305
审稿时长
3.5 months
期刊介绍: EJN is the journal of FENS and supports the international neuroscientific community by publishing original high quality research articles and reviews in all fields of neuroscience. In addition, to engage with issues that are of interest to the science community, we also publish Editorials, Meetings Reports and Neuro-Opinions on topics that are of current interest in the fields of neuroscience research and training in science. We have recently established a series of ‘Profiles of Women in Neuroscience’. Our goal is to provide a vehicle for publications that further the understanding of the structure and function of the nervous system in both health and disease and to provide a vehicle to engage the neuroscience community. As the official journal of FENS, profits from the journal are re-invested in the neuroscientific community through the activities of FENS.
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