94. ACUTE FATIGUE LEVELS ARE IMPROVED BY BRIEF STANDING BREAKS IN PROLONGED SITTING AMONG OLDER POSTMENOPAUSAL WOMEN.

IF 3.8 2区医学 Q1 GERIATRICS & GERONTOLOGY

American Journal of Geriatric Psychiatry Pub Date : 2025-07-14 DOI:10.1016/j.jagp.2025.04.096

Vanessa Garcia , Mario I. Hernandez , Shannon L. Wilson , Heather Anderson , Jeffrey S. Patterson , Ruohui Chen , Lindsay Dillon , Andrea Z. LaCroix , Rong W. Zablocki , Loki Natarajan , Dorothy D. Sears

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Abstract

Introduction

Fatigue is a prevalent symptom experienced in older adults. Prolonged sitting is associated with increased fatigue and adverse mental health. Emerging evidence shows that breaking up sitting time with light activity breaks or stands may reduce fatigue in sedentary workers and individuals with type 2 diabetes. However, little is known regarding the effect of breaking up sitting time on the acute fatigue levels in postmenopausal women. This study aimed to investigate the effect of interrupting sitting time with different standing interventions on the acute fatigue levels in older postmenopausal women.

Methods

This two-site, three-condition randomized controlled crossover trial, the Rise for Health - Lab study, enrolled postmenopausal women with overweight or obesity (n=79; mean ± SD age 67 ± 7 years and BMI 32.52 ± 5.15 kg/m2). Participants completed three 5-hr conditions in a clinical laboratory setting: frequent sit- to- stands (STS – 2-minute stand every 15 minutes), hourly standing breaks (HSB – 8-minute stand every hour), and prolonged sitting (control) in a randomized order, separated by a minimum 7-day washout period before crossover. The secondary outcome of fatigue was assessed hourly using the 18-item Lee Fatigue Scale, which yields a total fatigue score as well as fatigue and energy subscale scores. The net incremental area under the curve (iAUC) was investigated via linear mixed models to evaluate each interruption modality versus the control condition. The significance level was set as 0.025 to account for multiple comparisons (e.g., 2 intervention conditions vs. control).

Results

Seventy-six participants completed at least one study visit and were included in the analysis. After adjusting for site, STS significantly reduced mean iAUC fatigue subscale scores by 81% (-24.8, SE: 10.8, p=0.02) and mean iAUC total fatigue scores by 93% (-25.3, SE: 9.3, p=0.008) compared to the control. STS improved iAUC energy subscale score by 156% (26.4, SE: 10.6, p=0.01) compared to the control. The HSB condition was not associated with significant differences in the iAUC fatigue subscale score (p=0.26), iAUC energy subscale score (p=0.21), or iAUC total fatigue score (p=0.18) compared to the control condition.

Conclusions

Frequently breaking up prolonged sitting with brief standing breaks may reduce acute fatigue in postmenopausal women with overweight or obesity. These findings may provide geriatric practitioners and caregivers with a practical and feasible non-pharmacological option for the treatment of fatigue in older adults.

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94. 老年绝经后妇女在长时间坐着的情况下，短暂的站立休息可以改善急性疲劳水平。

疲劳是老年人的普遍症状。久坐会增加疲劳和对心理健康不利。越来越多的证据表明，通过轻度活动或站立来打破坐着的时间可能会减少久坐工作者和2型糖尿病患者的疲劳。然而，关于停止久坐对绝经后妇女急性疲劳程度的影响，我们所知甚少。本研究旨在探讨以不同站立干预措施打断久坐时间对老年绝经后妇女急性疲劳水平的影响。方法这项2点、3条件的随机对照交叉试验，即Rise for Health - Lab研究，纳入了绝经后体重超重或肥胖的妇女(n=79；平均±SD年龄67±7岁，BMI 32.52±5.15 kg/m2)。参与者在临床实验室环境中完成了三个5小时的条件：经常坐到站（STS -每15分钟站立2分钟），每小时站立休息（HSB -每小时站立8分钟）和长时间坐（对照组），随机顺序，在交叉之前至少有7天的洗脱期。疲劳的次要结果使用18项Lee疲劳量表每小时评估一次，该量表产生总疲劳得分以及疲劳和能量子量表得分。通过线性混合模型研究了净增量曲线下面积（iAUC），以评估每种中断方式与控制条件的关系。显著性水平设为0.025，以考虑多重比较（例如，2个干预条件与对照）。结果76名参与者至少完成了一次研究访问，并被纳入分析。经场地调整后，与对照组相比，STS显著降低了iAUC平均疲劳亚量表得分81% (-24.8,SE: 10.8, p=0.02)，平均iAUC总疲劳得分93% （-25.3,SE: 9.3, p=0.008）。与对照组相比，STS使iAUC能量分量量表得分提高了156% （26.4,SE: 10.6, p=0.01）。与对照组相比，HSB状态与iAUC疲劳亚量表评分（p=0.26）、iAUC能量亚量表评分（p=0.21）或iAUC总疲劳评分（p=0.18）均无显著差异。结论经常打破长时间的久坐，短暂的站立休息可以减轻绝经后超重或肥胖妇女的急性疲劳。这些发现可能为老年医生和护理人员提供一个实用可行的非药物治疗老年人疲劳的选择。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

American Journal of Geriatric Psychiatry 医学-精神病学

CiteScore

13.00

自引率

4.20%

发文量

381

审稿时长

26 days

期刊介绍： The American Journal of Geriatric Psychiatry is the leading source of information in the rapidly evolving field of geriatric psychiatry. This esteemed journal features peer-reviewed articles covering topics such as the diagnosis and classification of psychiatric disorders in older adults, epidemiological and biological correlates of mental health in the elderly, and psychopharmacology and other somatic treatments. Published twelve times a year, the journal serves as an authoritative resource for professionals in the field.