Base‐Promoted Synthesis of Indenones from Cyclopropenone via N‐atom Nucleophilicity on Imidazole or Amide

IF 4 2区化学 Q2 CHEMISTRY, APPLIED

Advanced Synthesis & Catalysis Pub Date : 2025-07-13 DOI:10.1002/adsc.70010

Dong‐Wei Wang, Shuo‐Xun Zheng, Jian‐Quan Liu, Xiang‐Shan Wang

引用次数: 0

Abstract

A base‐promoted domino reaction strategy has been developed for the synthesis of 3‐substituted 2‐phenylindenones through the nucleophilic ring‐opening of 2,3‐diphenylcyclopropenone by nitrogen atoms. This protocol encompasses a series of reactions, including Michael addition, ring‐opening, intramolecular Friedel–Crafts cyclization, and dehydrogenation, offering a transition‐metal‐free pathway to efficiently access indenone scaffolds.

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咪唑或酰胺的N原子亲核性催化环丙烯合成茚酮

本文提出了一种碱促进的多米诺反应策略，通过氮原子使2,3 -二苯基环丙烯亲核开环来合成3 -取代的2 -苯基烯酮。该方案包括一系列反应，包括Michael加成、开环、分子内Friedel-Crafts环化和脱氢，提供了一个无过渡金属的途径来有效地获得茚酮支架。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advanced Synthesis & Catalysis 化学-应用化学

CiteScore

9.40

自引率

7.40%

发文量

447

审稿时长

1.8 months

期刊介绍： Advanced Synthesis & Catalysis (ASC) is the leading primary journal in organic, organometallic, and applied chemistry. The high impact of ASC can be attributed to the unique focus of the journal, which publishes exciting new results from academic and industrial labs on efficient, practical, and environmentally friendly organic synthesis. While homogeneous, heterogeneous, organic, and enzyme catalysis are key technologies to achieve green synthesis, significant contributions to the same goal by synthesis design, reaction techniques, flow chemistry, and continuous processing, multiphase catalysis, green solvents, catalyst immobilization, and recycling, separation science, and process development are also featured in ASC. The Aims and Scope can be found in the Notice to Authors or on the first page of the table of contents in every issue.