Peng Ronggang, Meng Weilun, Du Lei, Qu Shen, Xu Yawei, Gao Changzheng, Gao Qizhong, Wang Xiaoyan
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引用次数: 0
Abstract
Background: Bariatric surgery is an effective method for weight reduction, and epicardial adipose tissue (EAT) is a recognized marker of cardiovascular disease risk. However, the impact of weight loss on EAT and the correlation between reduced body weight and changes in EAT remain unclear.
Objective: This study examines the impact of weight loss following laparoscopic sleeve gastrectomy (LSG) on EAT volume and its correlation with body mass index (BMI) reduction.
Setting: This study was conducted at 2 hospitals in China: the Affiliated Hospital of Jiangnan University and Shanghai 10th People's hospital.
Method: Consecutive patients who underwent LSG were screened for inclusion between August 2016 and December 2024. EAT parameters were assessed both preoperatively and 12 months postsurgery using the ITK-SNAP CT imaging technique. Additionally, indicators of cardiac structure and function were collected.
Results: A total of 88 patients were included. After 12 months, significant reductions were observed in EAT volume (402.73 ± 52.80 ml to 372.14 ± 51.70 ml, P < .001), left atrial diameter (LAD; 37.66 ± 3.70 mm to 35.03 ± 3.65 mm, P < .001), interventricular septum thickness (IVS; 10.18 ± .94 mm to 9.52 ± .88 mm, P < .001), and left ventricular mass (LVmass; 262.27 ± 59.59 g to 235.55 ± 47.99 g, P < .001). No significant changes were observed in left ventricular ejection fraction (LVEF; 64.43 ± 5.00% to 65.35 ± 3.03%, P = .084). Moreover, changes in BMI were positively correlated with changes in EAT (r = .509, P < .001), LAD (r = .219, P = .040), and IVS (r = .262, P = .014).
Conclusion: Significant improvement in EAT and cardiac structural remodeling occurs after LSG surgery, which strongly correlates with BMI reduction. EAT serves as a novel mediator in the relationship between obesity and cardiovascular disease, and bariatric surgery has the potential to mitigate cardiovascular risk by targeting this therapeutic focus.
背景：减肥手术是一种有效的减肥方法，心外膜脂肪组织（EAT）是公认的心血管疾病风险的标志。然而，减肥对EAT的影响以及体重减轻与EAT变化之间的相关性尚不清楚。目的：本研究探讨腹腔镜袖胃切除术（LSG）后体重减轻对胃食道容积的影响及其与体重指数（BMI）降低的相关性。背景：本研究在中国的两家医院进行：江南大学附属医院和上海市第十人民医院。方法：筛选2016年8月至2024年12月期间连续接受LSG治疗的患者。使用ITK-SNAP CT成像技术评估术前和术后12个月的EAT参数。采集心脏结构、功能指标。结果：共纳入88例患者。12个月后，进食容积（402.73±52.80 ml至372.14±51.70 ml, P < 0.001）、左房内径(LAD；37.66±3.70 mm ~ 35.03±3.65 mm, P < 0.001)，室间隔厚度(IVS；10.18±0.94 mm ~ 9.52±0.88 mm, P < 0.001)，左心室质量(LVmass；262.27±59.59 g ~ 235.55±47.99 g, P < 0.001)。左室射血分数（LVEF）无明显变化；64.43±5.00% ~ 65.35±3.03%,P = 0.084)。此外，BMI的变化与EAT （r = .509, P < .001）、LAD （r = .219, P = .040）、IVS （r = .262, P = .014）的变化呈正相关。结论：LSG手术后EAT和心脏结构重构明显改善，与BMI降低密切相关。在肥胖和心血管疾病之间的关系中，EAT是一种新的中介，减肥手术有可能通过靶向这一治疗重点来降低心血管风险。
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