{"title":"Exploring the mechanisms underlying the development and evolution of the mammalian cerebrum using gyrencephalic ferrets.","authors":"Kengo Saito, Narufumi Kameya, Nguyen Tai, Toshihide Hamabe-Horiike, Yohei Shinmyo, Hiroshi Kawasaki","doi":"10.1159/000546646","DOIUrl":null,"url":null,"abstract":"<p><p>The mammalian cerebrum has changed substantially during evolution. Neurons and glial cells have increased, and the cerebrum has expanded and folded. Although these evolutionary changes are believed to be important for acquiring higher cognitive functions, the molecular mechanisms underlying the development and evolution of the mammalian cerebrum are not fully understood. This is partially due to the difficulty in analyzing these mechanisms using only mice. To overcome this limitation, we developed genetic manipulation techniques for the cerebrum of gyrencephalic carnivore ferrets. Gene knockout in the ferret cerebrum was achieved using the CRISPR/Cas9 system. This review highlights recent research from our lab and others on the mechanisms underlying the development and evolution of cortical folds using ferrets.</p>","PeriodicalId":50585,"journal":{"name":"Developmental Neuroscience","volume":" ","pages":"1-28"},"PeriodicalIF":2.3000,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Developmental Neuroscience","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1159/000546646","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"DEVELOPMENTAL BIOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
The mammalian cerebrum has changed substantially during evolution. Neurons and glial cells have increased, and the cerebrum has expanded and folded. Although these evolutionary changes are believed to be important for acquiring higher cognitive functions, the molecular mechanisms underlying the development and evolution of the mammalian cerebrum are not fully understood. This is partially due to the difficulty in analyzing these mechanisms using only mice. To overcome this limitation, we developed genetic manipulation techniques for the cerebrum of gyrencephalic carnivore ferrets. Gene knockout in the ferret cerebrum was achieved using the CRISPR/Cas9 system. This review highlights recent research from our lab and others on the mechanisms underlying the development and evolution of cortical folds using ferrets.
期刊介绍：
''Developmental Neuroscience'' is a multidisciplinary journal publishing papers covering all stages of invertebrate, vertebrate and human brain development. Emphasis is placed on publishing fundamental as well as translational studies that contribute to our understanding of mechanisms of normal development as well as genetic and environmental causes of abnormal brain development. The journal thus provides valuable information for both physicians and biologists. To meet the rapidly expanding information needs of its readers, the journal combines original papers that report on progress and advances in developmental neuroscience with concise mini-reviews that provide a timely overview of key topics, new insights and ongoing controversies. The editorial standards of ''Developmental Neuroscience'' are high. We are committed to publishing only high quality, complete papers that make significant contributions to the field.
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