Role of Metabolic Syndrome in Male Fertility: Is It a Risk Factor?

IF 0.9 4区 医学 Q4 UROLOGY & NEPHROLOGY
Ali Egemen Avcı, Basri Çakıroğlu, Bekir Sami Uyanık, Muammer Kendirci, Mehmet Murad Başar
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Abstract

Background: Metabolic syndrome (MetS) is a significant health issue linked to male infertility through mechanisms such as aromatisation, hormonal imbalance, increased scrotal temperature, decreased testicular blood flow and increased DNA damage. This study evaluated the serum hormone levels and sperm parameters in men with idiopathic infertility on the basis of the presence or absence of MetS.

Methods: Infertile men were included. Height, weight and waist circumference were measured, and body mass index (BMI) was calculated. Blood pressure and biochemical parameters, including serum hormone levels, blood sugar, lipid profiles and semen analysis after 3-5 days of abstinence, were assessed. Participants were divided into two groups on the basis of the International Diabetes Federation criteria: Those with MetS (group I) and those without MetS (group II). Parameters were statistically compared between groups. Risk factors were assessed using logistic regression.

Results: A total of 518 infertile men were included, of whom 227 (43.8%) had MetS (group I) and 291 (56.2%) did not (group II). Significant differences were observed in all MetS criteria except low-density lipoprotein levels (p = 0.240). Serum testosterone levels were significantly lower in group I (p = 0.001). Although sperm parameters were lower in group I, but the differences were not statistically significant (p > 0.05). Age (odds ratio (OR): 1.075; 95% confidence interval (CI): 1.042-1.109; p < 0.001), medication use (OR: 1.675; 95% CI: 1.131-2.481; p = 0.01) and ejaculate volume (OR: 0.869; 95% CI: 0.772-0.978; p = 0.02) were found to be risk factors for MetS in regression analysis.

Conclusions: MetS may negatively influence the male reproductive system through various mechanisms. Further research is required to clarify the effect of MetS on male infertility.

代谢综合征在男性生育中的作用:它是一个危险因素吗?
背景:代谢综合征(MetS)是一个与男性不育相关的重要健康问题,其机制包括芳香化、激素失衡、阴囊温度升高、睾丸血流量减少和DNA损伤增加。本研究评估了男性特发性不育症患者血清激素水平和精子参数的基础上是否存在MetS。方法:纳入不育男性。测量身高、体重、腰围,计算体重指数(BMI)。禁欲3-5天后,评估血压和生化指标,包括血清激素水平、血糖、血脂和精液分析。根据国际糖尿病联合会的标准,参与者被分为两组:有MetS的(第一组)和没有MetS的(第二组)。组间参数进行统计学比较。采用logistic回归评估危险因素。结果:共纳入518例不育男性,其中ⅰ组有MetS 227例(43.8%),ⅱ组无MetS 291例(56.2%)。除低密度脂蛋白水平外,所有MetS标准均有显著差异(p = 0.240)。组患者血清睾酮水平显著降低(p = 0.001)。1组患者精子各项指标虽低于对照组,但差异无统计学意义(p < 0.05)。年龄(优势比(OR): 1.075;95%置信区间(CI): 1.042-1.109;p < 0.001)、药物使用(OR: 1.675;95% ci: 1.131-2.481;p = 0.01)和射精量(OR: 0.869;95% ci: 0.772-0.978;p = 0.02)为met的危险因素。结论:MetS可能通过多种机制对男性生殖系统产生负面影响。需要进一步的研究来阐明MetS对男性不育的影响。
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来源期刊
Archivos Espanoles De Urologia
Archivos Espanoles De Urologia UROLOGY & NEPHROLOGY-
CiteScore
0.90
自引率
0.00%
发文量
111
期刊介绍: Archivos Españoles de Urología published since 1944, is an international peer review, susbscription Journal on Urology with original and review articles on different subjets in Urology: oncology, endourology, laparoscopic, andrology, lithiasis, pediatrics , urodynamics,... Case Report are also admitted.
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