Prevalence and factors with potentially inappropriate prescribing among older outpatients with depression: a multicentre study across China.

IF 4.3 3区医学 Q1 PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH

Journal of Global Health Pub Date : 2025-07-11 DOI:10.7189/jogh.15.04216

Fangyuan Tian, Zhaoyan Chen, Ying Zhang

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引用次数: 0

Abstract

Background: Older outpatients with depression are at high risk for potentially inappropriate prescription (PIP). This investigation sought to determine the frequency and associated factors of PIP within Chinese older adults.

Methods: This cross-sectional study used prescription data from older outpatients with depression from 90 hospitals in seven cities in China from January-December 2021. Risk factor identification for PIP employed multivariate logistic regression analysis. Trend assessment was performed through joinpoint regression to calculate the average annual percent change.

Results: The prevalence of PIP reached 50.42%. The top five PIM were alprazolam, clonazepam, olanzapine, lorazepam, estazolam. The prevalence of PIP decreased from 51.56 to 50.99% (average annual percent change = -0.335%). Logistic regression demonstrated that tertiary-level hospital (odds ratio (OR) = 1.215; 95% confidence interval (CI) = 1.100, 1.342, P < 0.001), department of psychiatry (OR = 1.958; 95% CI = 1.855, 2.067, P < 0.001), age ≥80 (OR = 1.069; 95% CI = 1.016, 1.124, P = 0.01), more diseases (OR = 1.209; 95% CI = 1.092, 1.339, P < 0.001), polypharmacy (OR = 1.672; 95% CI = 1.541, 1.814, P < 0.001) exhibited positive links to PIP among older outpatients suffering from depression.

Conclusions: This investigation revealed that the occurrence of PIP in older outpatients with depression is high in China.

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中国老年抑郁症门诊患者的患病率及处方不当因素：一项多中心研究

背景：老年抑郁症门诊患者存在潜在不当处方（PIP）的高风险。本研究旨在确定中国老年人PIP的发生频率及其相关因素。方法：本横断面研究使用了2021年1月至12月中国7个城市90家医院老年抑郁症门诊患者的处方数据。对PIP的危险因素进行多因素logistic回归分析。采用联结点回归进行趋势评估，计算年平均变化百分比。结果：PIP患病率达50.42%。排在前五位的PIM分别是阿普唑仑、氯硝西泮、奥氮平、劳拉西泮、艾司唑仑。PIP患病率从51.56%下降到50.99%（年平均变化百分比为- 0.35%）。Logistic回归分析显示：三级医院(优势比(OR) = 1.215；95%可信区间(CI) = 1.100, 1.342， P结论：本调查显示，中国老年抑郁症门诊患者PIP发生率较高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Journal of Global Health PUBLIC, ENVIRONMENTAL & OCCUPATIONAL HEALTH -

CiteScore

6.10

自引率

2.80%

发文量

240

审稿时长

6 weeks

期刊介绍： Journal of Global Health is a peer-reviewed journal published by the Edinburgh University Global Health Society, a not-for-profit organization registered in the UK. We publish editorials, news, viewpoints, original research and review articles in two issues per year.