Effect of Magnesium Supplements on Improving Glucose Control, Blood Pressure and Lipid Profile in Patients With Type 2 Diabetes Mellitus: A systematic review and meta-analysis.

Q3 Medicine

Sultan Qaboos University Medical Journal Pub Date : 2025-05-02 DOI:10.18295/2075-0528.2848

Nasiba Al Maqrashi, Salim Al Busaidi, Sara Al-Rasbi, Abdullah M Al Alawi, Juhaina S Al-Maqbali

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Abstract

This study evaluated the effects of magnesium (Mg) supplementation on glycaemic control in type 2 diabetes mellitus through a meta-analysis of 23 randomised controlled trials involving 1,345 participants. Mg supplementation significantly increased serum Mg levels (weighted mean difference [WMD] = 0.69, 95% CI: 0.32 to 1.06) and reduced fasting blood glucose levels (WMD = -0.58, 95% CI: -0.87 to -0.28). However, the impact on glycated haemoglobin was minimal (WMD = -0.16, 95% CI: -0.32 to 0.00). Subgroup analysis showed a greater reduction in glycated haemoglobin among participants aged ≥65 years and those receiving longer durations of supplementation. Additionally, Mg supplementation was linked to lower diastolic blood pressure and potential improvements in lipid profile. This review highlights the importance of considering patient characteristics, dosage and intervention duration in future research on Mg supplementation for glycaemic control in diabetes.

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镁补充剂对改善2型糖尿病患者血糖控制、血压和血脂的影响：一项系统综述和荟萃分析

本研究通过对23项涉及1345名参与者的随机对照试验的荟萃分析，评估了镁（Mg）补充剂对2型糖尿病患者血糖控制的影响。补充Mg显著提高血清Mg水平（加权平均差[WMD] = 0.69, 95% CI: 0.32 ~ 1.06），降低空腹血糖水平（WMD = -0.58, 95% CI: -0.87 ~ -0.28）。然而，对糖化血红蛋白的影响很小（WMD = -0.16, 95% CI: -0.32至0.00）。亚组分析显示，在年龄≥65岁的参与者和接受较长时间补充的参与者中，糖化血红蛋白的减少幅度更大。此外，补充镁与降低舒张压和潜在的血脂改善有关。这篇综述强调了在未来糖尿病患者补充镁控制血糖的研究中考虑患者特征、剂量和干预时间的重要性。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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