{"title":"Plant-based Exosome Injections for Skin Wound Healing: Experimental Study.","authors":"Noury Adel, Nenad Stankovic, Gerardo Cervantes, Amira Gindi, Lamiaa Mohamed Shawky","doi":"10.1097/GOX.0000000000006949","DOIUrl":null,"url":null,"abstract":"<p><strong>Background: </strong>This study aimed to evaluate the impact of plant-derived exosome injections on the healing of skin wounds.</p><p><strong>Methods: </strong>A total of 18 Wistar Albino rats were included and randomly allocated into 2 groups. The first group underwent a scalpel incision on the ventral hand surface without any additional treatment. The second group received an identical incision, followed by injections of plant-based exosomes at the wound site. Tissue samples were collected at baseline, as well as on days 7 and 14, for histological assessment of wound healing. Hematoxylin and eosin and Masson trichrome staining were used to evaluate epithelial thickness, collagen deposition, and inflammatory cell infiltration.</p><p><strong>Results: </strong>The group receiving exosome injections exhibited a significantly enhanced wound healing response compared with the control group. Histological analysis revealed an increase in epithelial thickness, reduced inflammatory cell count, and greater collagen deposition with a more organized structural arrangement, indicating accelerated tissue repair. By day 14, wounds treated with exosomes demonstrated a well-formed epithelium and a substantial reduction in inflammation, highlighting the therapeutic potential of plant-derived exosomes in modulating wound healing dynamics.</p><p><strong>Conclusions: </strong>The administration of plant-based exosomes into skin wounds resulted in a notable improvement in the healing process. These findings suggest that exosome therapy may enhance tissue regeneration and expedite recovery, making it a promising approach for optimizing wound management and repair. Further research is warranted to explore its broader clinical applications.</p>","PeriodicalId":20149,"journal":{"name":"Plastic and Reconstructive Surgery Global Open","volume":"13 7","pages":"e6949"},"PeriodicalIF":1.5000,"publicationDate":"2025-07-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12245253/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Plastic and Reconstructive Surgery Global Open","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1097/GOX.0000000000006949","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/1 0:00:00","PubModel":"eCollection","JCR":"Q3","JCRName":"SURGERY","Score":null,"Total":0}
引用次数: 0
Abstract
Background: This study aimed to evaluate the impact of plant-derived exosome injections on the healing of skin wounds.
Methods: A total of 18 Wistar Albino rats were included and randomly allocated into 2 groups. The first group underwent a scalpel incision on the ventral hand surface without any additional treatment. The second group received an identical incision, followed by injections of plant-based exosomes at the wound site. Tissue samples were collected at baseline, as well as on days 7 and 14, for histological assessment of wound healing. Hematoxylin and eosin and Masson trichrome staining were used to evaluate epithelial thickness, collagen deposition, and inflammatory cell infiltration.
Results: The group receiving exosome injections exhibited a significantly enhanced wound healing response compared with the control group. Histological analysis revealed an increase in epithelial thickness, reduced inflammatory cell count, and greater collagen deposition with a more organized structural arrangement, indicating accelerated tissue repair. By day 14, wounds treated with exosomes demonstrated a well-formed epithelium and a substantial reduction in inflammation, highlighting the therapeutic potential of plant-derived exosomes in modulating wound healing dynamics.
Conclusions: The administration of plant-based exosomes into skin wounds resulted in a notable improvement in the healing process. These findings suggest that exosome therapy may enhance tissue regeneration and expedite recovery, making it a promising approach for optimizing wound management and repair. Further research is warranted to explore its broader clinical applications.
期刊介绍：
Plastic and Reconstructive Surgery—Global Open is an open access, peer reviewed, international journal focusing on global plastic and reconstructive surgery.Plastic and Reconstructive Surgery—Global Open publishes on all areas of plastic and reconstructive surgery, including basic science/experimental studies pertinent to the field and also clinical articles on such topics as: breast reconstruction, head and neck surgery, pediatric and craniofacial surgery, hand and microsurgery, wound healing, and cosmetic and aesthetic surgery. Clinical studies, experimental articles, ideas and innovations, and techniques and case reports are all welcome article types. Manuscript submission is open to all surgeons, researchers, and other health care providers world-wide who wish to communicate their research results on topics related to plastic and reconstructive surgery. Furthermore, Plastic and Reconstructive Surgery—Global Open, a complimentary journal to Plastic and Reconstructive Surgery, provides an open access venue for the publication of those research studies sponsored by private and public funding agencies that require open access publication of study results. Its mission is to disseminate high quality, peer reviewed research in plastic and reconstructive surgery to the widest possible global audience, through an open access platform. As an open access journal, Plastic and Reconstructive Surgery—Global Open offers its content for free to any viewer. Authors of articles retain their copyright to the materials published. Additionally, Plastic and Reconstructive Surgery—Global Open provides rapid review and publication of accepted papers.
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