Anti-LGI1 antibody-positive autoimmune encephalitis concurrent with neuropsychiatric systemic lupus erythematosus.

IF 1.9 4区 医学 Q3 RHEUMATOLOGY
Lupus Pub Date : 2025-09-01 Epub Date: 2025-07-11 DOI:10.1177/09612033251356106
Atsuhiko Sunaga, Takashi Kida, Shunsuke Fujieda, Shunya Kaneshita, Yuta Kojima, Takahiro Seno, Makoto Wada, Masataka Kohno, Yutaka Kawahito
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引用次数: 0

Abstract

Anti-leucine-rich glioma-inactivated protein 1 (LGI1) antibody-positive limbic encephalitis is a form of autoimmune encephalitis (AE). The importance of anti-LGI1 antibody in neuropsychiatric systemic lupus erythematosus (NPSLE) remains unclear. We present a 65-year-old woman with amnesia and disorientation, positive anti-LGI1 and anti-Smith antibodies, hyponatremia, leukopenia, and hypocomplementemia. Magnetic resonance imaging findings were consistent with limbic encephalitis and cervical myelitis. She was diagnosed with NPSLE with anti-LGI1-positive AE. High-dose glucocorticoids and intravenous cyclophosphamide led to sustained remission. This case suggests that NPSLE may coexist with anti-LGI1-positive AE, highlighting the potential importance of anti-LGI1 antibody testing in NPSLE and expanding the management of AE.

抗lgi1抗体阳性的自身免疫性脑炎并发神经精神系统性红斑狼疮。
抗富亮氨酸胶质瘤失活蛋白1 (LGI1)抗体阳性的边缘脑炎是自身免疫性脑炎(AE)的一种形式。抗lgi1抗体在神经精神系统性红斑狼疮(NPSLE)中的重要性尚不清楚。我们报告一位65岁女性,患有失忆和定向障碍,抗lgi1和抗smith抗体阳性,低钠血症,白细胞减少症和低补体血症。磁共振成像结果与边缘脑炎和子宫颈脊髓炎一致。她被诊断为NPSLE伴抗lgi1阳性AE。大剂量糖皮质激素和静脉注射环磷酰胺导致持续缓解。该病例提示NPSLE可能与抗lgi1阳性AE共存,突出了抗lgi1抗体检测在NPSLE中潜在的重要性,并扩大了AE的管理。
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来源期刊
Lupus
Lupus 医学-风湿病学
CiteScore
4.20
自引率
11.50%
发文量
225
审稿时长
1 months
期刊介绍: The only fully peer reviewed international journal devoted exclusively to lupus (and related disease) research. Lupus includes the most promising new clinical and laboratory-based studies from leading specialists in all lupus-related disciplines. Invaluable reading, with extended coverage, lupus-related disciplines include: Rheumatology, Dermatology, Immunology, Obstetrics, Psychiatry and Cardiovascular Research…
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