{"title":"Anti-LGI1 antibody-positive autoimmune encephalitis concurrent with neuropsychiatric systemic lupus erythematosus.","authors":"Atsuhiko Sunaga, Takashi Kida, Shunsuke Fujieda, Shunya Kaneshita, Yuta Kojima, Takahiro Seno, Makoto Wada, Masataka Kohno, Yutaka Kawahito","doi":"10.1177/09612033251356106","DOIUrl":null,"url":null,"abstract":"<p><p>Anti-leucine-rich glioma-inactivated protein 1 (LGI1) antibody-positive limbic encephalitis is a form of autoimmune encephalitis (AE). The importance of anti-LGI1 antibody in neuropsychiatric systemic lupus erythematosus (NPSLE) remains unclear. We present a 65-year-old woman with amnesia and disorientation, positive anti-LGI1 and anti-Smith antibodies, hyponatremia, leukopenia, and hypocomplementemia. Magnetic resonance imaging findings were consistent with limbic encephalitis and cervical myelitis. She was diagnosed with NPSLE with anti-LGI1-positive AE. High-dose glucocorticoids and intravenous cyclophosphamide led to sustained remission. This case suggests that NPSLE may coexist with anti-LGI1-positive AE, highlighting the potential importance of anti-LGI1 antibody testing in NPSLE and expanding the management of AE.</p>","PeriodicalId":18044,"journal":{"name":"Lupus","volume":" ","pages":"1073-1079"},"PeriodicalIF":1.9000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Lupus","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.1177/09612033251356106","RegionNum":4,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/7/11 0:00:00","PubModel":"Epub","JCR":"Q3","JCRName":"RHEUMATOLOGY","Score":null,"Total":0}
引用次数: 0
Abstract
Anti-leucine-rich glioma-inactivated protein 1 (LGI1) antibody-positive limbic encephalitis is a form of autoimmune encephalitis (AE). The importance of anti-LGI1 antibody in neuropsychiatric systemic lupus erythematosus (NPSLE) remains unclear. We present a 65-year-old woman with amnesia and disorientation, positive anti-LGI1 and anti-Smith antibodies, hyponatremia, leukopenia, and hypocomplementemia. Magnetic resonance imaging findings were consistent with limbic encephalitis and cervical myelitis. She was diagnosed with NPSLE with anti-LGI1-positive AE. High-dose glucocorticoids and intravenous cyclophosphamide led to sustained remission. This case suggests that NPSLE may coexist with anti-LGI1-positive AE, highlighting the potential importance of anti-LGI1 antibody testing in NPSLE and expanding the management of AE.
期刊介绍:
The only fully peer reviewed international journal devoted exclusively to lupus (and related disease) research. Lupus includes the most promising new clinical and laboratory-based studies from leading specialists in all lupus-related disciplines. Invaluable reading, with extended coverage, lupus-related disciplines include: Rheumatology, Dermatology, Immunology, Obstetrics, Psychiatry and Cardiovascular Research…