Application of Levi's Muscle Index in frailty assessment: comparison of bioimpedance measures among older adults.

IF 3.1 3区医学 Q1 MEDICINE, GENERAL & INTERNAL

Frontiers in Medicine Pub Date : 2025-06-26 eCollection Date: 2025-01-01 DOI:10.3389/fmed.2025.1525569

Kworweinski Lafontant, David H Fukuda, Estefania Zamarripa, Abigail L Tice, Jethro Raphael M Suarez, Chitra Banarjee, Dahee Kim, Jeffrey R Stout, Joon-Hyuk Park, Rui Xie, Ladda Thiamwong

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Abstract

Introduction: Frailty is prevalent among older adults and is characterized by reductions in physical function and muscle quality. Despite the emerging clinical utility of bioelectrical impedance analysis (BIA) and phase angle (PhA) as a bioimpedance index, little is known about how bioimpedance indices such as Levi's Muscle Index (LMI), reactance/height (Xc/Height), and resistance/height (R/Height), relate to physical function and frailty.

Methods: This cross-sectional study examined 208 community-dwelling older adults (female, n = 183; age = 74.2 ± 6.9 years; BMI = 30.4 ± 6.4 kg/m²) to compare physical function measures and bioimpedance indices across frailty categories determined by the FRAIL questionnaire. PhA, LMI, Xc/Height, and R/Height were all assessed at 50 kHz using a direct segmental multi-frequency InBody s10 BIA device. Physical function was assessed using handgrip strength, postural sway, Timed-Up-and-Go, and the Short Physical Performance Battery. Data were analyzed using Spearman rho (ρ) and Pearson r correlation coefficients, and group differences were examined using Kruskal-Wallis H tests and one-way ANOVA.

Results: PhA (r = -0.18, p = 0.01) and Xc/Height (r = -0.24, p < 0.001) were significantly associated with FRAIL scores. LMI and PhA were well correlated with each other (ρ = 0.76, p < 0.001), yet Xc/Height was the only bioimpedance index to significantly differ between frailty categories (F = 6.39, p = 0.002, ηp² = 0.06).

Conclusion: Results suggest Xc/Height may be the only bioimpedance index indicative of frailty among older adults. Given the variety of assessments used to categorize frailty, these conclusions may be limited to the use of the FRAIL questionnaire; future research should compare LMI and PhA using multiple frailty indices.

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李维斯肌肉指数在衰弱评估中的应用：老年人生物阻抗测量的比较。

简介：虚弱在老年人中普遍存在，其特征是身体功能和肌肉质量的下降。尽管生物电阻抗分析（BIA）和相位角（PhA）作为生物阻抗指数在临床应用越来越广泛，但人们对李维肌肉指数（LMI）、电抗/高度（Xc/ height）和电阻/高度（R/ height）等生物阻抗指数与身体功能和虚弱之间的关系知之甚少。方法：本横断面研究调查了208名居住在社区的老年人(女性，n = 183；年龄= 74.2±6.9岁；BMI = 30.4±6.4 kg/m2)，比较虚弱问卷确定的不同虚弱类别的身体功能测量和生物阻抗指数。PhA、LMI、Xc/Height和R/Height均使用直接分段多频InBody s10 BIA装置在50 kHz下进行评估。身体功能通过握力、姿势摇摆、定时起-走和短物理性能电池进行评估。采用Spearman （ρ）和Pearson r相关系数分析数据，采用Kruskal-Wallis H检验和单因素方差分析检验组间差异。结果：PhA （r = -0.18, p = 0.01）和Xc/Height （r = -0.24, p < 0.001）与虚弱评分显著相关。LMI和PhA之间存在良好的相关性（ρ = 0.76, p < 0.001），而Xc/Height是唯一在不同脆弱类别之间存在显著差异的生物阻抗指数（F = 6.39, p = 0.002, ηp2 = 0.06）。结论：结果提示Xc/Height可能是老年人虚弱的唯一生物阻抗指标。考虑到用于对虚弱进行分类的各种评估，这些结论可能仅限于使用虚弱问卷；未来的研究应采用多种脆弱性指标对LMI和PhA进行比较。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Frontiers in Medicine Medicine-General Medicine

CiteScore

5.10

自引率

5.10%

发文量

3710

审稿时长

12 weeks

期刊介绍： Frontiers in Medicine publishes rigorously peer-reviewed research linking basic research to clinical practice and patient care, as well as translating scientific advances into new therapies and diagnostic tools. Led by an outstanding Editorial Board of international experts, this multidisciplinary open-access journal is at the forefront of disseminating and communicating scientific knowledge and impactful discoveries to researchers, academics, clinicians and the public worldwide. In addition to papers that provide a link between basic research and clinical practice, a particular emphasis is given to studies that are directly relevant to patient care. In this spirit, the journal publishes the latest research results and medical knowledge that facilitate the translation of scientific advances into new therapies or diagnostic tools. The full listing of the Specialty Sections represented by Frontiers in Medicine is as listed below. As well as the established medical disciplines, Frontiers in Medicine is launching new sections that together will facilitate - the use of patient-reported outcomes under real world conditions - the exploitation of big data and the use of novel information and communication tools in the assessment of new medicines - the scientific bases for guidelines and decisions from regulatory authorities - access to medicinal products and medical devices worldwide - addressing the grand health challenges around the world