Diagnostic accuracy of 18F-FDG and 68 Ga-FAPi PET/CT for patients with gastric carcinoma: a systematic review and meta-analysis.

IF 2.5 4区医学 Q2 RADIOLOGY, NUCLEAR MEDICINE & MEDICAL IMAGING

Annals of Nuclear Medicine Pub Date : 2025-07-11 DOI:10.1007/s12149-025-02082-z

Dikhra Khan, Jasim Jaleel, Ankita Phulia, Sambit Sagar, Prateek Kaushik, Rakesh Kumar

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引用次数: 0

Abstract

Objective: This systematic review aims to assess the diagnostic performance of FDG PET/CT and FAPi PET/CT in patients with gastric carcinoma, specifically for the evaluation of primary tumors, metastatic lymph nodes, and metastatic lesions.

Methods: Following PRISMA guidelines, relevant databases were searched until January 20, 2023. Studies reporting histopathology or surgical outcomes as the reference standard were included. Pooled estimates of diagnostic accuracy were generated using meta-analysis.

Results: Six studies with 167 patients who underwent FDG PET/CT and 169 patients who underwent FAPi PET/CT were included. For the detection of primary gastric carcinoma, FDG PET/CT demonstrated a pooled sensitivity of 0.86 (95% CI 0.47-0.98) and specificity of 0.70 (95% CI 0.39-0.90). The pooled positive likelihood ratio was 2.9 (95% CI 1.0-8.4), and the negative likelihood ratio was 0.21 (95% CI 0.03-1.30). The diagnostic odds ratio was 14 (95% CI 1-224), and the area under the SROC curve was 0.82. For FAPi PET/CT, pooled sensitivity and specificity for detecting primary gastric carcinoma were 0.90 (95% CI 0.90-0.90) and 0.50 (95% CI 0.50-0.50), respectively. The pooled positive and negative likelihood ratios were 1.8 (95% CI 1.8-1.8) and 0.20 (95% CI 0.20-0.20), respectively. The diagnostic odds ratio was 9 (95% CI 9-9), and the area under the SROC curve was 0.54.

Conclusion: FAPi PET/CT demonstrated comparable diagnostic performance to FDG PET/CT in the diagnosis of primary gastric carcinoma, lymph nodal metastases, and metastatic lesions. When compared to histopathology or surgical findings, FAPi PET/CT showed good sensitivity, specificity, positive likelihood ratio, and negative likelihood ratio.

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18F-FDG和68ga - fapi PET/CT对胃癌患者的诊断准确性：系统回顾和荟萃分析

目的：本系统综述旨在评价FDG PET/CT和FAPi PET/CT对胃癌患者的诊断价值，特别是对原发肿瘤、转移淋巴结和转移灶的评估。方法：按照PRISMA指南，检索相关数据库至2023年1月20日。报告组织病理学或手术结果作为参考标准的研究被纳入。使用荟萃分析产生诊断准确性的汇总估计。结果：纳入6项研究，167例FDG PET/CT患者和169例FAPi PET/CT患者。对于原发性胃癌的检测，FDG PET/CT的敏感性为0.86 (95% CI 0.47-0.98)，特异性为0.70 （95% CI 0.39-0.90）。合并阳性似然比为2.9 (95% CI 1.0-8.4)，阴性似然比为0.21 （95% CI 0.03-1.30）。诊断优势比为14 (95% CI 1-224)， SROC曲线下面积为0.82。FAPi PET/CT检测原发性胃癌的敏感性和特异性分别为0.90 （95% CI 0.90-0.90）和0.50 （95% CI 0.50-0.50）。合并阳性和阴性似然比分别为1.8 （95% CI 1.8-1.8）和0.20 （95% CI 0.20-0.20）。诊断优势比为9 (95% CI 9-9)， SROC曲线下面积为0.54。结论：FAPi PET/CT与FDG PET/CT对原发性胃癌、淋巴结转移及转移灶的诊断性能相当。与组织病理学或手术结果相比，FAPi PET/CT表现出良好的敏感性、特异性、阳性似然比和阴性似然比。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Annals of Nuclear Medicine 医学-核医学

CiteScore

4.90

自引率

7.70%

发文量

111

审稿时长

4-8 weeks

期刊介绍： Annals of Nuclear Medicine is an official journal of the Japanese Society of Nuclear Medicine. It develops the appropriate application of radioactive substances and stable nuclides in the field of medicine. The journal promotes the exchange of ideas and information and research in nuclear medicine and includes the medical application of radionuclides and related subjects. It presents original articles, short communications, reviews and letters to the editor.