Development of the Pediatric Weight Questionnaire (PWQ™) for Children and Adolescents with Obesity

IF 4 3区医学 Q2 MEDICINE, RESEARCH & EXPERIMENTAL

Advances in Therapy Pub Date : 2025-07-11 DOI:10.1007/s12325-025-03277-6

Kristina S. Boye, Amy Clark, Chisom Kanu, Lisa M. Neff, Anne M. Skalicky

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引用次数: 0

Abstract

Introduction

Development of obesity management medications (OMMs) for use in children and adolescents calls for patient-reported outcome (PRO) measures to evaluate treatment efficacy. Existing weight-specific symptom and impact PROs are limited to age ≥ 11 years and may not fully capture treatment benefit of new OMMs.

Methods

A targeted literature review was conducted to identify obesity symptom and impact outcomes and weight-specific PROs relevant to children and adolescents 6–17 years of age. Concept elicitation (CE) interviews were conducted by telephone with children and adolescents, including parents of children 6–11 years of age, to identify relevant weight-specific concepts. Key concepts relevant to three developmental age groups—6–7, 8–11, and 12–17 years—informed the creation of a pediatric weight-specific PRO to assess key symptoms and impacts of obesity: the Pediatric Weight Questionnaire (PWQ). Cognitive interviews (CI) were conducted by telephone to assess the comprehension, relevance, and comprehensiveness of the PWQ across the three age groups.

Results

Eight domains were identified from the literature as relevant to pediatric obesity: physical symptoms, physical function, psychological health, emotional behavior/function, family and social relationships, school functioning, and health-related quality of life. No existing weight-specific PRO encompassing these domains was identified. Twenty CE interview participants (mean age 11.4 years, 60% female, 50% Hispanic/Latino) confirmed that physical symptoms and physical, emotional, and social impacts were most relevant to their weight experience. The 23-item PWQ for adolescents 12–17 years of age and the 17-item PWQ for children 8–11 years of age are self-administered, while the 13-item PWQ for children 6–7 years of age is interviewer-administered. The three versions of the PWQ were evaluated with 34 CI participants (mean age 12 years, 64.7% female, 17.6% Hispanic/Latino), who found the PWQ easy to complete, relevant, and comprehensive.

Conclusion

The PWQ provides a means of assessing the impact of obesity and benefits of treatment in children and adolescents 6–17 years of age with obesity. Study findings support the content validity of this new measure for use in pediatric obesity clinical trials and observational research.

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针对儿童和青少年肥胖的儿童体重问卷（PWQ™）的开发

儿童和青少年肥胖管理药物（OMMs）的发展需要患者报告的结果（PRO）措施来评估治疗效果。现有体重特异性症状和影响评价仅限于年龄≥11岁，可能无法完全捕捉到新omm的治疗益处。方法：通过有针对性的文献综述，确定6-17岁儿童和青少年的肥胖症状、影响结果和体重特异性PROs。通过电话对儿童和青少年（包括6-11岁儿童的父母）进行概念启发（CE）访谈，以确定相关的体重特定概念。与6-7岁、8-11岁和12-17岁三个发育年龄组相关的关键概念为儿童体重特异性PRO的创建提供了信息，以评估肥胖的主要症状和影响：儿童体重问卷（PWQ）。通过电话进行认知访谈（CI），评估三个年龄组对PWQ的理解、相关性和全面性。结果：从文献中确定了与儿童肥胖相关的八个领域：身体症状、身体功能、心理健康、情绪行为/功能、家庭和社会关系、学校功能和健康相关的生活质量。没有发现包含这些结构域的现有体重特异性PRO。20名CE访谈参与者（平均年龄11.4岁，60%为女性，50%为西班牙裔/拉丁裔）证实，身体症状以及身体、情绪和社会影响与他们的体重体验最为相关。12-17岁青少年的23项工作能力评估和8-11岁儿童的17项工作能力评估采用自我评估，而6-7岁儿童的13项工作能力评估采用访谈者评估。34名CI参与者（平均年龄12岁，64.7%为女性，17.6%为西班牙裔/拉丁裔）对三个版本的PWQ进行了评估，他们发现PWQ易于完成，相关且全面。结论：PWQ提供了一种评估肥胖对6-17岁肥胖儿童和青少年的影响和治疗效果的方法。研究结果支持这种新测量方法在儿童肥胖临床试验和观察性研究中的内容效度。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Advances in Therapy 医学-药学

CiteScore

7.20

自引率

2.60%

发文量

353

审稿时长

6-12 weeks

期刊介绍： Advances in Therapy is an international, peer reviewed, rapid-publication (peer review in 2 weeks, published 3–4 weeks from acceptance) journal dedicated to the publication of high-quality clinical (all phases), observational, real-world, and health outcomes research around the discovery, development, and use of therapeutics and interventions (including devices) across all therapeutic areas. Studies relating to diagnostics and diagnosis, pharmacoeconomics, public health, epidemiology, quality of life, and patient care, management, and education are also encouraged. The journal is of interest to a broad audience of healthcare professionals and publishes original research, reviews, communications and letters. The journal is read by a global audience and receives submissions from all over the world. Advances in Therapy will consider all scientifically sound research be it positive, confirmatory or negative data. Submissions are welcomed whether they relate to an international and/or a country-specific audience, something that is crucially important when researchers are trying to target more specific patient populations. This inclusive approach allows the journal to assist in the dissemination of all scientifically and ethically sound research.