Effect of Ramadan Fasting on Malondialdehyde, Poly (ADP-Ribose) Polymerase, Sirtuin 1, Nuclear Receptor Subfamily 1 Group D Member 1, and Transforming Growth Factor Beta in Chronic Kidney Disease: A Prospective Cohort Study.

IF 0.7 Q3 MEDICINE, GENERAL & INTERNAL

Acta medica Indonesiana Pub Date : 2025-04-01

Drajad Priyono, Eti Yerizel, Harnavi Harun, Netti Suharti

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引用次数: 0

Abstract

Background: Chronic kidney disease (CKD) is a global health problem with increasing prevalence. This study aims to analyze the effect of Ramadan fasting on important biomarkers in CKD patients.

Methods: A prospective cohort study was conducted on 30 CKD patients with stages 1, 2, and 3A who underwent Ramadan fasting. Measurements of MDA, PARP, SIRT1, NR1D1, and TGF-β levels were carried out before fasting, 2 weeks during fasting, and after fasting using the Enzyme-linked immunosorbent assay (ELISA) method.

Results: There were significant decreases in urea, fasting blood glucose, HbA1C, and uric acid levels (p<0.05). MDA and SIRT1 decreased significantly (p<0.001), while PARP and NR1D1 increased significantly (p<0.001). TGF-β also showed a decrease. There were no significant changes in lipid profiles, creatinine, and albumin.

Conclusion: Ramadan fasting has significant effects on several biochemical parameters and biological markers in early-stage CKD patients. These changes indicate potential improvements in oxidative stress, cell autophagy, inflammation regulation, and circadian rhythm. Further studies are needed to evaluate the long-term effects and clinical implications of these findings in CKD management.

本刊更多论文

斋月禁食对慢性肾病患者丙二醛、聚（adp -核糖）聚合酶、Sirtuin 1、核受体亚家族1组D成员1和转化生长因子β的影响：一项前瞻性队列研究

背景：慢性肾脏疾病（CKD）是一个全球性的健康问题，发病率越来越高。本研究旨在分析斋月禁食对CKD患者重要生物标志物的影响。方法：对30例斋月禁食的1期、2期和3A期CKD患者进行前瞻性队列研究。采用酶联免疫吸附试验（ELISA）法测定空腹前、空腹2周和空腹后各组小鼠的MDA、PARP、SIRT1、NR1D1和TGF-β水平。结果：早期CKD患者的尿素、空腹血糖、糖化血红蛋白、尿酸水平均显著降低(p)。结论：斋月禁食对早期CKD患者的多项生化指标和生物学指标有显著影响。这些变化表明氧化应激、细胞自噬、炎症调节和昼夜节律的潜在改善。需要进一步的研究来评估这些发现在CKD管理中的长期影响和临床意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Acta medica Indonesiana MEDICINE, GENERAL & INTERNAL-

CiteScore

2.30

自引率

0.00%

发文量

审稿时长

12 weeks

期刊介绍： Acta Medica Indonesiana – The Indonesian Journal of Internal Medicine is an open accessed online journal and comprehensive peer-reviewed medical journal published by the Indonesian Society of Internal Medicine since 1968. Our main mission is to encourage the novel and important science in the clinical area in internal medicine. We welcome authors for original articles (research), review articles, interesting case reports, special articles, clinical practices, and medical illustrations that focus on the clinical area of internal medicine. Subjects suitable for publication include, but are not limited to the following fields of: -Allergy and immunology -Emergency medicine -Cancer and stem cells -Cardiovascular -Endocrinology and Metabolism -Gastroenterology -Gerontology -Hematology -Hepatology -Tropical and Infectious Disease -Virology -Internal medicine -Psychosomatic -Pulmonology -Rheumatology -Renal and Hypertension -Thyroid