{"title":"Advances in Mechanochemical C─H Functionalization: A Comparative Study with Solvent-Based Approaches","authors":"Nanditha Kattukudiyil Narayanan, Michael Schnürch","doi":"10.1002/cctc.202500457","DOIUrl":null,"url":null,"abstract":"<p>This review provides an overview on recent progress in mechanochemical transition metal catalyzed C─H functionalization. Solventless operation and enhanced reaction efficiency makes mechanochemical synthesis a more sustainable alternative to conventional approaches. By including a comparison between mechanochemical methods and conventional solvent-based protocols, this review provides chemists with valuable insights into the relative efficiency and sustainability of these solventless strategies. This comparison enables informed decision-making when selecting methods for C─H functionalization based on specific needs. Moreover, the review identifies existing gaps in mechanochemical C─H functionalization and discusses necessary steps to establish it as a mainstream approach. By bridging these gaps, chemists can further enhance the utility and adoption of mechanochemical methodologies, contributing to more sustainable practices in synthetic chemistry.</p>","PeriodicalId":141,"journal":{"name":"ChemCatChem","volume":"17 13","pages":""},"PeriodicalIF":3.9000,"publicationDate":"2025-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://onlinelibrary.wiley.com/doi/epdf/10.1002/cctc.202500457","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"ChemCatChem","FirstCategoryId":"92","ListUrlMain":"https://onlinelibrary.wiley.com/doi/10.1002/cctc.202500457","RegionNum":3,"RegionCategory":"化学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q2","JCRName":"CHEMISTRY, PHYSICAL","Score":null,"Total":0}
引用次数: 0
Abstract
This review provides an overview on recent progress in mechanochemical transition metal catalyzed C─H functionalization. Solventless operation and enhanced reaction efficiency makes mechanochemical synthesis a more sustainable alternative to conventional approaches. By including a comparison between mechanochemical methods and conventional solvent-based protocols, this review provides chemists with valuable insights into the relative efficiency and sustainability of these solventless strategies. This comparison enables informed decision-making when selecting methods for C─H functionalization based on specific needs. Moreover, the review identifies existing gaps in mechanochemical C─H functionalization and discusses necessary steps to establish it as a mainstream approach. By bridging these gaps, chemists can further enhance the utility and adoption of mechanochemical methodologies, contributing to more sustainable practices in synthetic chemistry.
期刊介绍：
With an impact factor of 4.495 (2018), ChemCatChem is one of the premier journals in the field of catalysis. The journal provides primary research papers and critical secondary information on heterogeneous, homogeneous and bio- and nanocatalysis. The journal is well placed to strengthen cross-communication within between these communities. Its authors and readers come from academia, the chemical industry, and government laboratories across the world. It is published on behalf of Chemistry Europe, an association of 16 European chemical societies, and is supported by the German Catalysis Society.
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