Understanding Aortic Stenosis and Transcatheter Aortic Valve Replacement in Women

IF 2.8 Q3 CARDIAC & CARDIOVASCULAR SYSTEMS

Structural Heart Pub Date : 2025-07-01 DOI:10.1016/j.shj.2025.100666

Giulia Masiero MD , Anna Franzone MD, PhD , Valeria Paradies MD , Nicole Karam MD, PhD , Chiara Fraccaro MD, PhD , Chiara De Biase MD , Mirvat Alasnag MD , Giulia Botti MD , Angelicarosa Cascone MD , Ana Belen Cid-Alvarez MD, PhD , Tanja K. Rudolph MD, PhD , Marta Kaluzna-Oleksy MD, PhD , Stephane Manzo-Silberman MD, PhD , Julinda Mehilli MD, PhD , Barbara E. Stähli MD, PhD , Julia Grapsa MD, PhD , Kyriakos Panaou MD , Barbara Bellini MD , Joanna J. Wykrzykowska MD, PhD , Sabine Bleiziffer MD, PhD , Alaide Chieffo MD, PhD

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引用次数: 0

Abstract

The impact of sex on the baseline characteristics, morphology, and clinical presentation of degenerative aortic stenosis (AS) is well-documented but remains poorly understood. Unlike valve surgery, for which patients have been predominantly male, percutaneous treatment of AS has shown balanced representation of both sexes, with women demonstrating greater benefit from transfemoral aortic valve replacement compared to surgical treatment. This review explores sex-specific differences in the epidemiology, pathophysiology, diagnostic challenges, treatment approaches, and clinical outcomes of degenerative AS. Furthermore, it addresses technical, sex-specific considerations in transfemoral aortic valve replacement, including preprocedural screening, device selection, implantation strategy, and postprocedural management.

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了解女性主动脉瓣狭窄和经导管主动脉瓣置换术

性别对退行性主动脉瓣狭窄（AS）的基线特征、形态和临床表现的影响已被充分记录，但仍知之甚少。与瓣膜手术患者以男性为主不同，经皮治疗AS的男女比例均衡，与手术治疗相比，经股主动脉瓣置换术对女性的益处更大。这篇综述探讨了变性AS的流行病学、病理生理学、诊断挑战、治疗方法和临床结果的性别特异性差异。此外，它还讨论了经股主动脉瓣置换术中技术性、性别特异性的考虑因素，包括术前筛查、设备选择、植入策略和术后管理。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Structural Heart Medicine-Cardiology and Cardiovascular Medicine

CiteScore

1.60

自引率

0.00%

发文量