Evaluate the Gln223Arg LEPR genotype variation in T2DM patients with chronic kidney disease

Q2 Medicine

Obesity Medicine Pub Date : 2025-07-01 DOI:10.1016/j.obmed.2025.100630

Shahab Ahmed Salıh Gezh , Figen Guzelgul , Nihan Bozkurt , Hakan Sivgin , Koksal Deveci

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引用次数: 0

Abstract

Background

Obesity significantly contributes to the development of type 2 diabetes mellitus (T2DM). Genetic variations in leptin receptor (LEPR) genes are thought to be influential in the onset of T2DM in patients with kidney malfunction and obesity. This study focused on examining the link between the Gln223Arg polymorphism in the LEPR gene and T2DM in the mid-Black Sea region of the Anatolian Turkish population.

Methodology

In this study, we examined a group of 174 patients with T2DM and compared them to a control group of 30 healthy individuals to explore the relationship involving the leptin receptor gene (Gln223Arg). The T2DM group was divided into 91 patients with macroproteinuria and 46 patients with normoproteinuria subgroups. The genetic analysis was conducted using the polymerase chain reaction-based restriction fragment length polymorphism (PCR-RFLP) technique.

Results

Our data revealed a significant increase in the frequency of gene polymorphism with HbA1c levels.

Conclusion

The Gln223Arg leptin receptor gene mutation may cause an elevation of HbA1c in T2DM patients with chronic kidney disease (CKD) in the mid-Black Sea region of the Anatolian Turkish population.

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评估Gln223Arg LEPR基因型在T2DM合并慢性肾病患者中的变异

背景：肥胖与2型糖尿病（T2DM）的发生有显著关系。瘦素受体（LEPR）基因的遗传变异被认为对肾功能障碍和肥胖患者的T2DM发病有影响。本研究的重点是研究黑海中部地区安纳托利亚土耳其人LEPR基因Gln223Arg多态性与T2DM之间的联系。在这项研究中，我们检查了一组174例T2DM患者，并将其与30名健康个体的对照组进行比较，以探讨瘦素受体基因（Gln223Arg）的关系。T2DM组分为大蛋白尿组91例和正常蛋白尿组46例。采用基于聚合酶链反应的限制性片段长度多态性（PCR-RFLP）技术进行遗传分析。结果我们的数据显示，基因多态性的频率随着HbA1c水平的升高而显著增加。结论Gln223Arg瘦素受体基因突变可能导致安纳托利亚土耳其人口中黑海地区T2DM合并慢性肾脏疾病（CKD）患者HbA1c升高。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Obesity Medicine Medicine-Public Health, Environmental and Occupational Health

CiteScore

5.50

自引率

0.00%

发文量

审稿时长

40 days

期刊介绍： The official journal of the Shanghai Diabetes Institute Obesity is a disease of increasing global prevalence with serious effects on both the individual and society. Obesity Medicine focusses on health and disease, relating to the very broad spectrum of research in and impacting on humans. It is an interdisciplinary journal that addresses mechanisms of disease, epidemiology and co-morbidities. Obesity Medicine encompasses medical, societal, socioeconomic as well as preventive aspects of obesity and is aimed at researchers, practitioners and educators alike.