Histone modifications: key mechanisms in embryo implantation of domestic animal

IF 2.5 2区农林科学 Q3 REPRODUCTIVE BIOLOGY

Theriogenology Pub Date : 2025-07-08 DOI:10.1016/j.theriogenology.2025.117568

Yiwen Sha , Xue Qin , Weijun Pang

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引用次数: 0

Abstract

Embryo implantation is a critical event in the reproductive development of domestic animals, where research on this process holds significant practical importance for enhancing animal production efficiency and reducing embryo loss. As an essential epigenetic regulatory mechanism, histone modifications can profoundly influence cell function and developmental processes by altering chromatin structure and gene expression patterns. In recent years, with the continuous development of epigenetic technologies, more and more studies have begun to reveal the important roles of histone modifications in embryonic development. This review specifically highlights the regulation of embryo activation, endometrial receptivity and decidualization by histone modifications in farm animals, aiming to provide a comprehensive understanding of their impact on embryo implantation. From this perspective, in-depth research on histone modifications in livestock species can not only offer new insights into the molecular regulatory mechanisms of embryo implantation but also enhance our understanding of reproductive development in farm animals.

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组蛋白修饰：家畜胚胎着床的关键机制

胚胎着床是家畜生殖发育的关键环节，研究这一过程对提高动物生产效率和减少胚胎损失具有重要的现实意义。组蛋白修饰作为一种重要的表观遗传调控机制，可以通过改变染色质结构和基因表达模式，深刻影响细胞功能和发育过程。近年来，随着表观遗传技术的不断发展，越来越多的研究开始揭示组蛋白修饰在胚胎发育中的重要作用。本文重点综述了家畜组蛋白修饰对胚胎激活、子宫内膜容受性和去个体化的调控，旨在全面了解它们对胚胎着床的影响。从这个角度来看，深入研究家畜物种的组蛋白修饰不仅可以为胚胎着床的分子调控机制提供新的见解，而且可以增强我们对农场动物生殖发育的认识。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Theriogenology 农林科学-生殖生物学

CiteScore

5.50

自引率

14.30%

发文量

387

审稿时长

72 days

期刊介绍： Theriogenology provides an international forum for researchers, clinicians, and industry professionals in animal reproductive biology. This acclaimed journal publishes articles on a wide range of topics in reproductive and developmental biology, of domestic mammal, avian, and aquatic species as well as wild species which are the object of veterinary care in research or conservation programs.